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10.4049/jimmunol.1402295 http://scihub22266oqcxt.onion/10.4049/jimmunol.1402295 C4417391!4417391!25862817     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 194 (10): 4846-59 Nephropedia Template TP {{tp|p=25862817|t=2015. Obesity increases mortality and modulates the lung metabolome during pandemic H1N1 influenza virus infection in mice1 |pdf=|usr=}}{{25862817}} gab.com Text Obesity increases mortality and modulates the lung metabolome during pandemic H1N1 influenza virus infection in mice1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25862817 #FOAvip Obese individuals are at greater risk for hospitalization and death from infection with the 2009 pandemic H1N1 influenza virus (pH1N1). In this study, diet-induced and genetic-induced obese mouse models were utilized to uncover potential mechanisms by which obesity increases pH1N1 severity. High fat diet-induced and genetic-induced obese mice exhibited greater pH1N1 mortality, lung inflammatory responses and excess lung damage despite similar levels of viral burden compared with lean control mice. Further, obese mice had fewer bronchoalveolar macrophages and regulatory T cells during infection. Obesity is inherently a metabolic disease, and metabolic profiling has found widespread usage in metabolic and infectious disease models for identifying biomarkers and enhancing understanding of complex mechanisms of disease. To further characterize the consequences of obesity on pH1N1 infection responses, we performed global liquid chromatography-mass spectrometry metabolic profiling of lung tissue and urine. An array of metabolites were perturbed by obesity both prior to and during infection. Uncovered metabolic signatures were used to identify changes in metabolic pathways that were differentially altered in the lungs of obese mice such as fatty acid, phospholipid, and nucleotide metabolism. Taken together, obesity induces distinct alterations in the lung metabolome, perhaps contributing to aberrant pH1N1 immune responses. Twit Text FOAVip Obesity increases mortality and modulates the lung metabolome during pandemic H1N1 influenza virus infection in mice1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25862817 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25862817 #FOAvip English Wikipedia <ref>{{Cite pmid|25862817}}</ref> Obesity increases mortality and modulates the lung metabolome during pandemic H1N1 influenza virus infection in mice1 #MMPMID25862817 Milner JJ; Rebeles J; Dhungana S; Stewart DA; Sumner SC; Meyers MH; Mancuso P; Beck MA J Immunol 2015[May]; 194 (10): 4846-59 PMID25862817show ga Obese individuals are at greater risk for hospitalization and death from infection with the 2009 pandemic H1N1 influenza virus (pH1N1). In this study, diet-induced and genetic-induced obese mouse models were utilized to uncover potential mechanisms by which obesity increases pH1N1 severity. High fat diet-induced and genetic-induced obese mice exhibited greater pH1N1 mortality, lung inflammatory responses and excess lung damage despite similar levels of viral burden compared with lean control mice. Further, obese mice had fewer bronchoalveolar macrophages and regulatory T cells during infection. Obesity is inherently a metabolic disease, and metabolic profiling has found widespread usage in metabolic and infectious disease models for identifying biomarkers and enhancing understanding of complex mechanisms of disease. To further characterize the consequences of obesity on pH1N1 infection responses, we performed global liquid chromatography-mass spectrometry metabolic profiling of lung tissue and urine. An array of metabolites were perturbed by obesity both prior to and during infection. Uncovered metabolic signatures were used to identify changes in metabolic pathways that were differentially altered in the lungs of obese mice such as fatty acid, phospholipid, and nucleotide metabolism. Taken together, obesity induces distinct alterations in the lung metabolome, perhaps contributing to aberrant pH1N1 immune responses. äObesity increases mortality and modulates the lung metabolome during p(epmc).pdf DeepDyve Pubget Overpricing