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10.1016/j.jss.2015.02.004 http://scihub22266oqcxt.onion/10.1016/j.jss.2015.02.004 C4417390!4417390!25748104     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Surg+Res 2015 ; 195 (2): 541-9 Nephropedia Template TP {{tp|p=25748104|t=2015. Murine Lung Cancer Induces Generalized T Cell Exhaustion |pdf=|usr=}}{{25748104}} gab.com Text Murine Lung Cancer Induces Generalized T Cell Exhaustion JO: J Surg Res http://www.kidney.de/pget.php?&tw=1&pmid=25748104 #FOAvip Background: Cancer is known to modulate tumor-specific immune responses by establishing a micro-environment that leads to the upregulation of T cell inhibitory receptors, resulting in the progressive loss of function and eventual death of tumor-specific T cells. However, the ability of cancer to impact the functionality of the immune system on a systemic level is much less well characterized. Because cancer is known to predispose patients to infectious complications including sepsis, we hypothesized that the presence of cancer alters pathogen-directed immune responses on a systemic level. Materials and Methods: We assessed systemic T cell coinhibitory receptor expression, cytokine production, and apoptosis in mice with established subcutaneous lung cancer tumors and in unmanipulated mice without cancer. Results: Results indicated that the frequencies of PD-1+, BTLA+, and 2B4+ cells in both the CD4+ and CD8+ T cell compartments were increased in mice with localized cancer relative to non-cancer controls, and the frequencies of both CD4+ and CD8+ T cells expressing multiple different inhibitory receptors was increased in cancer animals relative to non-cancer controls. Additionally, 2B4+CD8+ T cells in cancer mice exhibited reduced IL-2 and IFN-?, while BTLA+CD8+ T cells in cancer mice exhibited reduced IL-2 and TNF. Conversely, CD4+ T cells in cancer animals demonstrated an increase in the frequency of Annexin V+ apoptotic cells. Conclusion: Taken together, these data suggest that the presence of cancer induces systemic T cell exhaustion and generalized immune suppression. Twit Text FOAVip Murine Lung Cancer Induces Generalized T Cell Exhaustion ????J Surg Res http://www.kidney.de/pget.php?&tw=1&pmid=25748104 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25748104 #FOAvip English Wikipedia <ref>{{Cite pmid|25748104}}</ref> Murine Lung Cancer Induces Generalized T Cell Exhaustion #MMPMID25748104 Mittal R; Chen CW; Lyons JD; Margoles LM; Liang Z; Coopersmith CM; Ford ML J Surg Res 2015[May]; 195 (2): 541-9 PMID25748104show ga Background: Cancer is known to modulate tumor-specific immune responses by establishing a micro-environment that leads to the upregulation of T cell inhibitory receptors, resulting in the progressive loss of function and eventual death of tumor-specific T cells. However, the ability of cancer to impact the functionality of the immune system on a systemic level is much less well characterized. Because cancer is known to predispose patients to infectious complications including sepsis, we hypothesized that the presence of cancer alters pathogen-directed immune responses on a systemic level. Materials and Methods: We assessed systemic T cell coinhibitory receptor expression, cytokine production, and apoptosis in mice with established subcutaneous lung cancer tumors and in unmanipulated mice without cancer. Results: Results indicated that the frequencies of PD-1+, BTLA+, and 2B4+ cells in both the CD4+ and CD8+ T cell compartments were increased in mice with localized cancer relative to non-cancer controls, and the frequencies of both CD4+ and CD8+ T cells expressing multiple different inhibitory receptors was increased in cancer animals relative to non-cancer controls. Additionally, 2B4+CD8+ T cells in cancer mice exhibited reduced IL-2 and IFN-?, while BTLA+CD8+ T cells in cancer mice exhibited reduced IL-2 and TNF. Conversely, CD4+ T cells in cancer animals demonstrated an increase in the frequency of Annexin V+ apoptotic cells. Conclusion: Taken together, these data suggest that the presence of cancer induces systemic T cell exhaustion and generalized immune suppression. äMurine Lung Cancer Induces Generalized T Cell Exhaustion (epmc).pdf DeepDyve Pubget Overpricing