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10.1016/j.tim.2015.01.012

http://scihub22266oqcxt.onion/10.1016/j.tim.2015.01.012
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C4417389!4417389!25701111
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suck abstract from ncbi

pmid25701111      Trends+Microbiol 2015 ; 23 (5): 296-300
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  • Fueling type III secretion #MMPMID25701111
  • Lee PC; Rietsch A
  • Trends Microbiol 2015[May]; 23 (5): 296-300 PMID25701111show ga
  • Type III secretion systems are complex nanomachines that export proteins from the bacterial cytoplasm across the cell envelope in a single step. They are at the core of the machinery used to assemble the bacterial flagellum, and the needle complex many Gram-negative pathogens use to inject effector proteins into host cells and cause disease. Several models have been put forward to explain how this export is energized, and the mechanism has been the subject of considerable debate. Here we present an overview of these models and discuss their relative merits. Recent evidence suggests that the proton motive force is the primary energy source for type III secretion, although contribution from refolding of secreted proteins has not been ruled out. The mechanism, by which the proton motive force is converted to protein export, remains enigmatic.
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