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10.1186/s12890-015-0023-1 http://scihub22266oqcxt.onion/10.1186/s12890-015-0023-1 C4417263!4417263!25887144     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Pulm+Med 2015 ; 15 (ä): ä Nephropedia Template TP {{tp|p=25887144|t=2015. Ventilation inhomogeneities in children with congenital thoracic malformations |pdf=|usr=}}{{25887144}} gab.com Text Ventilation inhomogeneities in children with congenital thoracic malformations JO: BMC Pulm Med http://www.kidney.de/pget.php?&tw=1&pmid=25887144 #FOAvip Background: Congenital thoracic malformations (CTM) are rare lung lesions that are managed with surgical resection or active surveillance.The objective of this study was to comprehensively assess large and small airway function in children with CTM who underwent lobectomy in early life.We hypothesise that sensitive measures of lung function will demonstrate residual impairments in CTM compared to healthy children. Methods: Nitrogen lung clearance index (LCI), reactance and resistance (X5Hz and R5Hz), forced expiratory volume in 1?s and forced vital capacity (FEV1 and FVC) were prospectively measured in 10 children with CTM (mean age/SD: 7.6/1.3) who had undergone surgical resection in early life and in 17 healthy children (mean age/SD: 4.8/0.4). Total lung capacity (TLC) was also conducted in children older than 7 years of age with CTM (n?=?8). Results: Mean LCI was 8.0 (95% CI 7.5 to 8.5) in the CTM group and 7.3 (95% CI 7.0 to 7.6) in healthy children (p?=?0.016). Mean X5Hz was ?0.44kPa/l/s (95% CI ?0.58 to ?0.31) in the CTM group and ?0.31kPa/l/s (95% CI ?0.35 to ?0.27) in healthy children (p?=?0.02). Mean Z score for X5Hz was ?2.11 (95% CI ?3.59 to ?0.63) in the CTM group and ?0.11 (95% CI ?0.55 to 0.33) in healthy children (p?=?0.0008). Mean FEV1 was 1.21 L (95% CI 0.97 to 1.45) in the CTM group and 1.02 L (95% CI 0.90 to 1.15) in healthy children (p?=?0.22). Mean % predicted FEV1 was 83% (95% CI 74 to 92) in the CTM group and 97% (95% CI 87 to 107) in healthy children (p?<?0.05). Mean % predicted TLC in CTM children was 121.3% (95% CI 88.45 to 154.1). Mean LCI was inversely correlated with height z-scores in the CTM group (rs?=??0.88, p?=?0.002) but not in healthy children (rs?=?0.22, p?=?0.4). Conclusions: Children with CTM have impaired lung function as demonstrated by the significant differences in LCI, reactance and FEV1 but not FVC, resistance and TLC. These findings may be of clinical relevance as ventilation inhomogeneities are closely correlated with somatic growth in this study. Electronic supplementary material: The online version of this article (doi:10.1186/s12890-015-0023-1) contains supplementary material, which is available to authorized users. Twit Text FOAVip Ventilation inhomogeneities in children with congenital thoracic malformations ????BMC Pulm Med http://www.kidney.de/pget.php?&tw=1&pmid=25887144 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25887144 #FOAvip English Wikipedia <ref>{{Cite pmid|25887144}}</ref> Ventilation inhomogeneities in children with congenital thoracic malformations #MMPMID25887144 Mandaliya PH; Morten M; Kumar R; James A; Deshpande A; Murphy VE; Gibson PG; Whitehead B; Robinson P; Mattes J BMC Pulm Med 2015[]; 15 (ä): ä PMID25887144show ga Background: Congenital thoracic malformations (CTM) are rare lung lesions that are managed with surgical resection or active surveillance.The objective of this study was to comprehensively assess large and small airway function in children with CTM who underwent lobectomy in early life.We hypothesise that sensitive measures of lung function will demonstrate residual impairments in CTM compared to healthy children. Methods: Nitrogen lung clearance index (LCI), reactance and resistance (X5Hz and R5Hz), forced expiratory volume in 1?s and forced vital capacity (FEV1 and FVC) were prospectively measured in 10 children with CTM (mean age/SD: 7.6/1.3) who had undergone surgical resection in early life and in 17 healthy children (mean age/SD: 4.8/0.4). Total lung capacity (TLC) was also conducted in children older than 7 years of age with CTM (n?=?8). Results: Mean LCI was 8.0 (95% CI 7.5 to 8.5) in the CTM group and 7.3 (95% CI 7.0 to 7.6) in healthy children (p?=?0.016). Mean X5Hz was ?0.44kPa/l/s (95% CI ?0.58 to ?0.31) in the CTM group and ?0.31kPa/l/s (95% CI ?0.35 to ?0.27) in healthy children (p?=?0.02). Mean Z score for X5Hz was ?2.11 (95% CI ?3.59 to ?0.63) in the CTM group and ?0.11 (95% CI ?0.55 to 0.33) in healthy children (p?=?0.0008). Mean FEV1 was 1.21 L (95% CI 0.97 to 1.45) in the CTM group and 1.02 L (95% CI 0.90 to 1.15) in healthy children (p?=?0.22). Mean % predicted FEV1 was 83% (95% CI 74 to 92) in the CTM group and 97% (95% CI 87 to 107) in healthy children (p? äVentilation inhomogeneities in children with congenital thoracic malfo(epmc).pdf DeepDyve Pubget Overpricing