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10.1007/s00125-014-3379-5 http://scihub22266oqcxt.onion/10.1007/s00125-014-3379-5 C4417192!4417192!25249235     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetologia 2014 ; 57 (12): 2566-75 Nephropedia Template TP {{tp|p=25249235|t=2014. Exposure of Embryonic Pancreas to Metformin Enhances the Number of Pancreatic Progenitors |pdf=|usr=}}{{25249235}} gab.com Text Exposure of Embryonic Pancreas to Metformin Enhances the Number of Pancreatic Progenitors JO: Diabetologia http://www.kidney.de/pget.php?&tw=1&pmid=25249235 #FOAvip Aims: Developing beta cells are vulnerable to nutrient environmental signals. Early developmental processes that alter the number of pancreatic progenitors can determine the number of beta cells present at birth. Metformin, the most widely used oral agent for diabetes, alters intracellular energy status in part by increasing AMP-activated protein kinase (AMPK) signaling. This study examined the effect of metformin on the developing pancreas and beta cells. Methods: Pancreatic rudiments at embryonic day 13.0 (E13.0) were cultured with metformin or AICAR (an AMPK activator) or vehicle control in vitro. In another set of studies, pregnant mice were treated with metformin throughout gestation. Embryonic (E14.0) and neonatal pancreata were then analyzed for their morphometry. Results: In vitro metformin treatment led to an increase in the proliferation and number of PDX1+ progenitors. These results were reproduced by in vitro culture of embryonic pancreas rudiments with AICAR, suggesting that AMPK activation was involved. Similarly, Metformin administration to pregnant dams induced an increase in both PDX1+ and NGN3+ progenitors in the embryonic pancreas at E14.0 and these changes resulted in an increased beta cell fraction in neonates. Conclusions: These results indicate that gestational metformin exposure modulates early steps of beta cell development (prior to E14.0) to increase the number of pancreatic and endocrine progenitors and these changes ultimately result in a higher beta cell fraction at birth. These findings are of clinical importance given that metformin is currently used for the treatment of gestational diabetes. Twit Text FOAVip Exposure of Embryonic Pancreas to Metformin Enhances the Number of Pancreatic Progenitors ????Diabetologia http://www.kidney.de/pget.php?&tw=1&pmid=25249235 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25249235 #FOAvip English Wikipedia <ref>{{Cite pmid|25249235}}</ref> Exposure of Embryonic Pancreas to Metformin Enhances the Number of Pancreatic Progenitors #MMPMID25249235 Gregg B; Elghazi L; Alejandro EU; Smith MR; Blandino-Rosano M; El-Gabri D; Cras-Méneur C; Bernal-Mizrachi E Diabetologia 2014[Dec]; 57 (12): 2566-75 PMID25249235show ga Aims: Developing beta cells are vulnerable to nutrient environmental signals. Early developmental processes that alter the number of pancreatic progenitors can determine the number of beta cells present at birth. Metformin, the most widely used oral agent for diabetes, alters intracellular energy status in part by increasing AMP-activated protein kinase (AMPK) signaling. This study examined the effect of metformin on the developing pancreas and beta cells. Methods: Pancreatic rudiments at embryonic day 13.0 (E13.0) were cultured with metformin or AICAR (an AMPK activator) or vehicle control in vitro. In another set of studies, pregnant mice were treated with metformin throughout gestation. Embryonic (E14.0) and neonatal pancreata were then analyzed for their morphometry. Results: In vitro metformin treatment led to an increase in the proliferation and number of PDX1+ progenitors. These results were reproduced by in vitro culture of embryonic pancreas rudiments with AICAR, suggesting that AMPK activation was involved. Similarly, Metformin administration to pregnant dams induced an increase in both PDX1+ and NGN3+ progenitors in the embryonic pancreas at E14.0 and these changes resulted in an increased beta cell fraction in neonates. Conclusions: These results indicate that gestational metformin exposure modulates early steps of beta cell development (prior to E14.0) to increase the number of pancreatic and endocrine progenitors and these changes ultimately result in a higher beta cell fraction at birth. These findings are of clinical importance given that metformin is currently used for the treatment of gestational diabetes. äExposure of Embryonic Pancreas to Metformin Enhances the Number of Pan(epmc).pdf DeepDyve Pubget Overpricing