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10.1038/ncb3158 http://scihub22266oqcxt.onion/10.1038/ncb3158 C4417000!4417000!25915125     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2015 ; 17 (5): 665-77 Nephropedia Template TP {{tp|p=25915125|t=2015. The ITIM-containing receptor LAIR1 is essential for acute myeloid leukemia development |pdf=|usr=}}{{25915125}} gab.com Text The ITIM-containing receptor LAIR1 is essential for acute myeloid leukemia development JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25915125 #FOAvip Conventional strategies are not particularly successful in treatment of leukemia, and identification of signaling pathways crucial to the activity of leukemia stem cells will provide targets for the development of new therapies. Here we report that certain receptors containing the immunoreceptor tyrosine-based inhibition motif (ITIM) are crucial for the development of acute myeloid leukemia (AML). Inhibition of expression of the ITIM-containing receptor LAIR1 does not affect normal hematopoiesis but abolishes leukemia development. LAIR1 induces activation of SHP-1, which acts as a phosphatase-independent signaling adaptor to recruit CAMK1 for activation of downstream CREB in AML cells. The LAIR1/SHP-1/CAMK1/CREB pathway sustains the survival and self-renewal of AML stem cells. Intervention in the signaling initiated by ITIM-containing receptors such as LAIR1 may result in successful treatment of AML. Twit Text FOAVip The ITIM-containing receptor LAIR1 is essential for acute myeloid leukemia development ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25915125 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25915125 #FOAvip English Wikipedia <ref>{{Cite pmid|25915125}}</ref> The ITIM-containing receptor LAIR1 is essential for acute myeloid leukemia development #MMPMID25915125 Kang X; Lu Z; Cui C; Deng M; Fan Y; Dong B; Han X; Xie F; Tyner JW; Coligan JE; Collins RH; Xiao X; You MJ; Zhang CC Nat Cell Biol 2015[May]; 17 (5): 665-77 PMID25915125show ga Conventional strategies are not particularly successful in treatment of leukemia, and identification of signaling pathways crucial to the activity of leukemia stem cells will provide targets for the development of new therapies. Here we report that certain receptors containing the immunoreceptor tyrosine-based inhibition motif (ITIM) are crucial for the development of acute myeloid leukemia (AML). Inhibition of expression of the ITIM-containing receptor LAIR1 does not affect normal hematopoiesis but abolishes leukemia development. LAIR1 induces activation of SHP-1, which acts as a phosphatase-independent signaling adaptor to recruit CAMK1 for activation of downstream CREB in AML cells. The LAIR1/SHP-1/CAMK1/CREB pathway sustains the survival and self-renewal of AML stem cells. Intervention in the signaling initiated by ITIM-containing receptors such as LAIR1 may result in successful treatment of AML. äThe ITIM-containing receptor LAIR1 is essential for acute myeloid leuk(epmc).pdf DeepDyve Pubget Overpricing