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10.1074/jbc.M115.639351 http://scihub22266oqcxt.onion/10.1074/jbc.M115.639351 C4416873!4416873 !25767119     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25767119 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2015 ; 290 (18 ): 11729-40 Nephropedia Template TP {{tp|p=25767119 |t=2015. Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor ? (TGF-?) pathway |pdf=|usr=}}{{25767119 }} gab.com Text Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor (TGF- ) pathway JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25767119 #FOAvip Specific p53 mutations abrogate tumor-suppressive functions by gaining new abilities to promote tumorigenesis. Inactivation of p53 is known to distort TGF-? signaling, which paradoxically displays both tumor-suppressive and pro-oncogenic functions. The molecular mechanisms of how mutant p53 simultaneously antagonizes the tumor-suppressive and synergizes the tumor-promoting function of the TGF-? pathway remain elusive. Here we demonstrate that mutant p53 differentially regulates subsets of TGF-? target genes by enhanced binding to the MH2 domain in Smad3 upon the integration of ERK signaling, therefore disrupting Smad3/Smad4 complex formation. Silencing Smad2, inhibition of ERK, or introducing a phosphorylation-defective mutation at Ser-392 in p53 abrogates the R175H mutant p53-dependent regulation of these TGF-? target genes. Our study shows a mechanism to reconcile the seemingly contradictory observations that mutant p53 can both attenuate and cooperate with the TGF-? pathway to promote cancer cell malignancy in the same cell type. Twit Text FOAVip Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor (TGF- ) pathway ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25767119 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25767119 #FOAvip English Wikipedia <ref>{{Cite pmid|25767119 }}</ref> Mutant p53 promotes tumor cell malignancy by both positive and negative regulation of the transforming growth factor ? (TGF-?) pathway #MMPMID25767119 Ji L ; Xu J ; Liu J ; Amjad A ; Zhang K ; Liu Q ; Zhou L ; Xiao J ; Li X J Biol Chem 2015[May]; 290 (18 ): 11729-40 PMID25767119 show ga Specific p53 mutations abrogate tumor-suppressive functions by gaining new abilities to promote tumorigenesis. Inactivation of p53 is known to distort TGF-? signaling, which paradoxically displays both tumor-suppressive and pro-oncogenic functions. The molecular mechanisms of how mutant p53 simultaneously antagonizes the tumor-suppressive and synergizes the tumor-promoting function of the TGF-? pathway remain elusive. Here we demonstrate that mutant p53 differentially regulates subsets of TGF-? target genes by enhanced binding to the MH2 domain in Smad3 upon the integration of ERK signaling, therefore disrupting Smad3/Smad4 complex formation. Silencing Smad2, inhibition of ERK, or introducing a phosphorylation-defective mutation at Ser-392 in p53 abrogates the R175H mutant p53-dependent regulation of these TGF-? target genes. Our study shows a mechanism to reconcile the seemingly contradictory observations that mutant p53 can both attenuate and cooperate with the TGF-? pathway to promote cancer cell malignancy in the same cell type. |*Mutation [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Extracellular Signal-Regulated MAP Kinases/metabolism [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Lung Neoplasms/pathology [MESH] |Mice [MESH] |Mutant Proteins/*genetics/*metabolism [MESH] |Smad2 Protein/metabolism [MESH] |Smad3 Protein/metabolism [MESH] |Snail Family Transcription Factors [MESH] |Transcription Factors/metabolism [MESH] |Transcription, Genetic [MESH] |Transforming Growth Factor beta/*metabolism [MESH]Mutant p53 promotes tumor cell malignancy by both positive and negativ(epmc).pdf DeepDyve Pubget Overpricing