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10.1074/jbc.M114.635086

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suck abstract from ncbi


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pmid25792747      J+Biol+Chem 2015 ; 290 (18): 11704-14
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  • Carboxyl Terminus of HSC70-interacting Protein (CHIP) Down-regulates NF-?B-inducing Kinase (NIK) and Suppresses NIK-induced Liver Injury* #MMPMID25792747
  • Jiang B; Shen H; Chen Z; Yin L; Zan L; Rui L
  • J Biol Chem 2015[May]; 290 (18): 11704-14 PMID25792747show ga
  • Background: Abnormal NIK expression and activation trigger liver injury.Results: CHIP bound to NIK and promoted NIK ubiquitination/degradation; liver-specific overexpression of NIK triggered fatal liver injury; and coexpression of CHIP reversed NIK detrimental effects.Conclusion: CHIP negatively regulates NIK and protects against NIK-induced liver injury.Significance: This study sheds light on a novel regulation of the NIK pathways by CHIP.
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