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10.1074/jbc.M114.623264

http://scihub22266oqcxt.onion/10.1074/jbc.M114.623264
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C4416862!4416862!25787080
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suck abstract from ncbi


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pmid25787080      J+Biol+Chem 2015 ; 290 (18): 11591-600
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  • Zinc Inhibits Hedgehog Autoprocessing: LINKING ZINC DEFICIENCY WITH HEDGEHOG ACTIVATION* #MMPMID25787080
  • Xie J; Owen T; Xia K; Singh AV; Tou E; Li L; Arduini B; Li H; Wan LQ; Callahan B; Wang C
  • J Biol Chem 2015[May]; 290 (18): 11591-600 PMID25787080show ga
  • Background: In many types of cancers zinc deficiency and overproduction of Hedgehog (Hh) ligand co-exist.Results: Zinc binds to the active site of the Hedgehog-intein (Hint) domain and inhibits Hh ligand production both in vitro and in cell culture.Conclusion: Zinc influences the Hh autoprocessing.Significance: This study uncovers a novel mechanistic link between zinc and the Hh signaling pathway.
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