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10.1074/jbc.M114.620237 http://scihub22266oqcxt.onion/10.1074/jbc.M114.620237 C4416861!4416861 !25787077     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25787077 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2015 ; 290 (18 ): 11578-90 Nephropedia Template TP {{tp|p=25787077 |t=2015. The coordinate cellular response to insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-2 (IGFBP-2) is regulated through vimentin binding to receptor tyrosine phosphatase ? (RPTP?) |pdf=|usr=}}{{25787077 }} gab.com Text The coordinate cellular response to insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-2 (IGFBP-2) is regulated through vimentin binding to receptor tyrosine phosphatase (RPTP ) JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25787077 #FOAvip Insulin-like growth factor-binding protein-2 (IGFBP-2) functions coordinately with IGF-I to stimulate cellular proliferation and differentiation. IGFBP-2 binds to receptor tyrosine phosphatase ? (RPTP?), and this binding in conjunction with IGF-I receptor stimulation induces RPTP? polymerization leading to phosphatase and tensin homolog inactivation, AKT stimulation, and enhanced cell proliferation. To determine the mechanism by which RPTP? polymerization is regulated, we analyzed the protein(s) that associated with RPTP? in response to IGF-I and IGFBP-2 in vascular smooth muscle cells. Proteomic experiments revealed that IGF-I stimulated the intermediate filament protein vimentin to bind to RPTP?, and knockdown of vimentin resulted in failure of IGFBP-2 and IGF-I to stimulate RPTP? polymerization. Knockdown of IGFBP-2 or inhibition of IGF-IR tyrosine kinase disrupted vimentin/RPTP? association. Vimentin binding to RPTP? was mediated through vimentin serine phosphorylation. The serine threonine kinase PKC? was recruited to vimentin in response to IGF-I and inhibition of PKC? activation blocked these signaling events. A cell-permeable peptide that contained the vimentin phosphorylation site disrupted vimentin/RPTP? association, and IGF-I stimulated RPTP? polymerization and AKT activation. Integrin-linked kinase recruited PKC? to SHPS-1-associated vimentin in response to IGF-I and inhibition of integrin-linked kinase/PKC? association reduced vimentin serine phosphorylation. PKC? stimulation of vimentin phosphorylation required high glucose and vimentin/RPTP?-association occurred only during hyperglycemia. Disruption of vimetin/RPTP? in diabetic mice inhibited RPTP? polymerization, vimentin serine phosphorylation, and AKT activation in response to IGF-I, whereas nondiabetic mice showed no difference. The induction of vimentin phosphorylation is important for IGFBP-2-mediated enhancement of IGF-I-stimulated proliferation during hyperglycemia, and it coordinates signaling between these two receptor-linked signaling systems. Twit Text FOAVip The coordinate cellular response to insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-2 (IGFBP-2) is regulated through vimentin binding to receptor tyrosine phosphatase (RPTP ) ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25787077 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25787077 #FOAvip English Wikipedia <ref>{{Cite pmid|25787077 }}</ref> The coordinate cellular response to insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-2 (IGFBP-2) is regulated through vimentin binding to receptor tyrosine phosphatase ? (RPTP?) #MMPMID25787077 Shen X ; Xi G ; Wai C ; Clemmons DR J Biol Chem 2015[May]; 290 (18 ): 11578-90 PMID25787077 show ga Insulin-like growth factor-binding protein-2 (IGFBP-2) functions coordinately with IGF-I to stimulate cellular proliferation and differentiation. IGFBP-2 binds to receptor tyrosine phosphatase ? (RPTP?), and this binding in conjunction with IGF-I receptor stimulation induces RPTP? polymerization leading to phosphatase and tensin homolog inactivation, AKT stimulation, and enhanced cell proliferation. To determine the mechanism by which RPTP? polymerization is regulated, we analyzed the protein(s) that associated with RPTP? in response to IGF-I and IGFBP-2 in vascular smooth muscle cells. Proteomic experiments revealed that IGF-I stimulated the intermediate filament protein vimentin to bind to RPTP?, and knockdown of vimentin resulted in failure of IGFBP-2 and IGF-I to stimulate RPTP? polymerization. Knockdown of IGFBP-2 or inhibition of IGF-IR tyrosine kinase disrupted vimentin/RPTP? association. Vimentin binding to RPTP? was mediated through vimentin serine phosphorylation. The serine threonine kinase PKC? was recruited to vimentin in response to IGF-I and inhibition of PKC? activation blocked these signaling events. A cell-permeable peptide that contained the vimentin phosphorylation site disrupted vimentin/RPTP? association, and IGF-I stimulated RPTP? polymerization and AKT activation. Integrin-linked kinase recruited PKC? to SHPS-1-associated vimentin in response to IGF-I and inhibition of integrin-linked kinase/PKC? association reduced vimentin serine phosphorylation. PKC? stimulation of vimentin phosphorylation required high glucose and vimentin/RPTP?-association occurred only during hyperglycemia. Disruption of vimetin/RPTP? in diabetic mice inhibited RPTP? polymerization, vimentin serine phosphorylation, and AKT activation in response to IGF-I, whereas nondiabetic mice showed no difference. The induction of vimentin phosphorylation is important for IGFBP-2-mediated enhancement of IGF-I-stimulated proliferation during hyperglycemia, and it coordinates signaling between these two receptor-linked signaling systems. |Amino Acid Sequence [MESH] |Animals [MESH] |Humans [MESH] |Insulin-Like Growth Factor Binding Protein 2/*metabolism/pharmacology [MESH] |Insulin-Like Growth Factor I/*metabolism/pharmacology [MESH] |Mice [MESH] |Molecular Sequence Data [MESH] |Phosphorylation/drug effects [MESH] |Protein Binding/drug effects [MESH] |Protein Multimerization/drug effects [MESH] |Protein Structure, Quaternary [MESH] |Receptor-Like Protein Tyrosine Phosphatases, Class 5/chemistry/*metabolism [MESH] |Signal Transduction/drug effects [MESH] |Swine [MESH]The coordinate cellular response to insulin-like growth factor-I (IGF-(epmc).pdf DeepDyve Pubget Overpricing