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10.1074/jbc.M115.640763 http://scihub22266oqcxt.onion/10.1074/jbc.M115.640763 C4416860!4416860!25767115     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2015 ; 290 (18): 11569-77 Nephropedia Template TP {{tp|p=25767115|t=2015. Intracellular Na+ Regulates Epithelial Na+ Channel Maturation* |pdf=|usr=}}{{25767115}} gab.com Text Intracellular Na+ Regulates Epithelial Na+ Channel Maturation* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25767115 #FOAvip Background: ENaC activity decreases when intracellular Na+ is elevated.Results: High intracellular Na+ inhibits N-glycan remodeling and prevents proteolytic processing by endogenous and exogenous proteases.Conclusion: Na+ inhibits ENaC maturation within the biosynthetic pathway.Significance: This work provides novel insights into the mechanisms underlying Na+ feedback inhibition and demonstrates that intracellular Na+ regulates ENaC biogenesis. Twit Text FOAVip Intracellular Na+ Regulates Epithelial Na+ Channel Maturation* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25767115 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25767115 #FOAvip English Wikipedia <ref>{{Cite pmid|25767115}}</ref> Intracellular Na+ Regulates Epithelial Na+ Channel Maturation* #MMPMID25767115 Heidrich E; Carattino MD; Hughey RP; Pilewski JM; Kleyman TR; Myerburg MM J Biol Chem 2015[May]; 290 (18): 11569-77 PMID25767115show ga Background: ENaC activity decreases when intracellular Na+ is elevated.Results: High intracellular Na+ inhibits N-glycan remodeling and prevents proteolytic processing by endogenous and exogenous proteases.Conclusion: Na+ inhibits ENaC maturation within the biosynthetic pathway.Significance: This work provides novel insights into the mechanisms underlying Na+ feedback inhibition and demonstrates that intracellular Na+ regulates ENaC biogenesis. äIntracellular Na+ Regulates Epithelial Na+ Channel Maturation* (epmc).pdf DeepDyve Pubget Overpricing