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10.1074/jbc.M114.623686

http://scihub22266oqcxt.onion/10.1074/jbc.M114.623686
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C4416839!4416839!25720492
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suck abstract from ncbi

pmid25720492      J+Biol+Chem 2015 ; 290 (18): 11337-48
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  • Selective Insulin Resistance in Adipocytes* #MMPMID25720492
  • Tan SX; Fisher-Wellman KH; Fazakerley DJ; Ng Y; Pant H; Li J; Meoli CC; Coster ACF; Stöckli J; James DE
  • J Biol Chem 2015[May]; 290 (18): 11337-48 PMID25720492show ga
  • Background: Insulin resistance is an early risk factor for metabolic disease.Results: Using various insulin resistance models, insulin regulation of glucose metabolism was universally blunted, whereas other actions (protein synthesis and anti-lipolysis) were unimpaired.Conclusion: Insulin resistance is selective for glucose metabolism in adipocytes.Significance: Chronic hyperactivation of unaffected insulin action pathways in the context of the metabolic syndrome likely contributes to disease progression.
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