Selective Insulin Resistance in Adipocytes* #MMPMID25720492
Tan SX; Fisher-Wellman KH; Fazakerley DJ; Ng Y; Pant H; Li J; Meoli CC; Coster ACF; Stöckli J; James DE
J Biol Chem 2015[May]; 290 (18): 11337-48 PMID25720492show ga
Background: Insulin resistance is an early risk factor for metabolic disease.Results: Using various insulin resistance models, insulin regulation of glucose metabolism was universally blunted, whereas other actions (protein synthesis and anti-lipolysis) were unimpaired.Conclusion: Insulin resistance is selective for glucose metabolism in adipocytes.Significance: Chronic hyperactivation of unaffected insulin action pathways in the context of the metabolic syndrome likely contributes to disease progression.