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10.1111/bcp.12557 http://scihub22266oqcxt.onion/10.1111/bcp.12557 C4415709!4415709!25408230     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Clin+Pharmacol 2015 ; 79 (5): 720-32 Nephropedia Template TP {{tp|p=25408230|t=2015. Lessons learned from the clinical development of oral peptides |pdf=|usr=}}{{25408230}} gab.com Text Lessons learned from the clinical development of oral peptides JO: Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25408230 #FOAvip The oral delivery of peptides and proteins has been hampered by an array of obstacles. However, several promising novel oral delivery systems have been developed. This paper reviews the most advanced oral formulation technologies, and highlights key lessons and implications from studies undertaken to date with these oral formulations. Special interest is given to oral salmon calcitonin (CT), glucagon-like peptide-1 (GLP-1), insulin, PYY-(3-36), recombinant human parathyroid hormone (rhPTH(1-31)-NH2) and PTH(1-34), by different technologies. The issues addressed include (i) interaction with water, (ii) interaction with food, (iii) diurnal variation, (iv) inter- and intra-subject variability, (v) correlation between efficacy and exposure and (vi) key deliverables of different technologies. These key lessons may aid research in the development of other oral formulations. Twit Text FOAVip Lessons learned from the clinical development of oral peptides ????Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25408230 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25408230 #FOAvip English Wikipedia <ref>{{Cite pmid|25408230}}</ref> Lessons learned from the clinical development of oral peptides #MMPMID25408230 Karsdal MA; Riis BJ; Mehta N; Stern W; Arbit E; Christiansen C; Henriksen K Br J Clin Pharmacol 2015[May]; 79 (5): 720-32 PMID25408230show ga The oral delivery of peptides and proteins has been hampered by an array of obstacles. However, several promising novel oral delivery systems have been developed. This paper reviews the most advanced oral formulation technologies, and highlights key lessons and implications from studies undertaken to date with these oral formulations. Special interest is given to oral salmon calcitonin (CT), glucagon-like peptide-1 (GLP-1), insulin, PYY-(3-36), recombinant human parathyroid hormone (rhPTH(1-31)-NH2) and PTH(1-34), by different technologies. The issues addressed include (i) interaction with water, (ii) interaction with food, (iii) diurnal variation, (iv) inter- and intra-subject variability, (v) correlation between efficacy and exposure and (vi) key deliverables of different technologies. These key lessons may aid research in the development of other oral formulations. äLessons learned from the clinical development of oral peptides (epmc).pdf DeepDyve Pubget Overpricing