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10.1097/WCO.0000000000000201 http://scihub22266oqcxt.onion/10.1097/WCO.0000000000000201 C4414882!4414882 !25887767     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25887767 &cmd=llinks): Failed to open stream: HTTP request failed! 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Novel syndromes associated with JC virus infection of neurons and meningeal cells: no longer a gray area |pdf=|usr=}}{{25887767 }} gab.com Text Novel syndromes associated with JC virus infection of neurons and meningeal cells: no longer a gray area JO: Curr Opin Neurol http://www.kidney.de/pget.php?&tw=1&pmid=25887767 #FOAvip PURPOSE OF REVIEW: The availability of a growing number of immunomodulatory medications over the past few years has been associated with various JC virus (JCV)-associated brain syndromes in patients with autoimmune diseases, including multiple sclerosis, Crohn's disease, and psoriasis that had not been previously recognized as predisposing factors for progressive multifocal leukoencephalopathy. This review covers the three novel syndromes discovered in the last decade that are caused by JCV infection of neurons and meningeal cells. RECENT FINDINGS: For more than 30 years, JCV was thought to exclusively infect oligodendrocytes and astrocytes in the white matter of the brain of immunosuppressed individuals. We now recognize that JCV-infected glial cells are frequently located at the gray-white matter junction or exclusively within the gray matter causing demyelination in the cortex. Mutations in JCV can trigger a change in tropism leading to involvement of other cell types, such as neurons and meningeal cells, causing clinically distinct entities. These new features of JCV infection provide challenges for clinicians taking care of affected patients and investigators studying the biology of this polyomavirus, its pathogenesis, and tropism. SUMMARY: We hope that increasing awareness of these syndromes will lead to early diagnosis, and pave the way for new avenues of research to better understand all aspects of JCV pathogenesis and develop efficient therapies for our patients. However, we need to remain vigilant and open to the possibility that additional JC variants or yet unknown polyomaviruses may also be associated with neurological diseases. Twit Text FOAVip Novel syndromes associated with JC virus infection of neurons and meningeal cells: no longer a gray area ????Curr Opin Neurol http://www.kidney.de/pget.php?&tw=1&pmid=25887767 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25887767 #FOAvip English Wikipedia <ref>{{Cite pmid|25887767 }}</ref> Novel syndromes associated with JC virus infection of neurons and meningeal cells: no longer a gray area #MMPMID25887767 Miskin DP ; Koralnik IJ Curr Opin Neurol 2015[Jun]; 28 (3 ): 288-94 PMID25887767 show ga PURPOSE OF REVIEW: The availability of a growing number of immunomodulatory medications over the past few years has been associated with various JC virus (JCV)-associated brain syndromes in patients with autoimmune diseases, including multiple sclerosis, Crohn's disease, and psoriasis that had not been previously recognized as predisposing factors for progressive multifocal leukoencephalopathy. This review covers the three novel syndromes discovered in the last decade that are caused by JCV infection of neurons and meningeal cells. RECENT FINDINGS: For more than 30 years, JCV was thought to exclusively infect oligodendrocytes and astrocytes in the white matter of the brain of immunosuppressed individuals. We now recognize that JCV-infected glial cells are frequently located at the gray-white matter junction or exclusively within the gray matter causing demyelination in the cortex. Mutations in JCV can trigger a change in tropism leading to involvement of other cell types, such as neurons and meningeal cells, causing clinically distinct entities. These new features of JCV infection provide challenges for clinicians taking care of affected patients and investigators studying the biology of this polyomavirus, its pathogenesis, and tropism. SUMMARY: We hope that increasing awareness of these syndromes will lead to early diagnosis, and pave the way for new avenues of research to better understand all aspects of JCV pathogenesis and develop efficient therapies for our patients. However, we need to remain vigilant and open to the possibility that additional JC variants or yet unknown polyomaviruses may also be associated with neurological diseases. |*Polyomavirus Infections/pathology/physiopathology/virology [MESH] |Animals [MESH] |Dura Mater/*pathology [MESH] |Humans [MESH] |JC Virus/*pathogenicity [MESH]Novel syndromes associated with JC virus infection of neurons and meni(epmc).pdf DeepDyve Pubget Overpricing