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10.1007/s00441-014-2088-1 http://scihub22266oqcxt.onion/10.1007/s00441-014-2088-1 C4414737!4414737!25616555     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Tissue+Res 2015 ; 360 (2): 321-32 Nephropedia Template TP {{tp|p=25616555|t=2015. The scaffolding protein GOPC regulates tight junction structure |pdf=|usr=}}{{25616555}} gab.com Text The scaffolding protein GOPC regulates tight junction structure JO: Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=25616555 #FOAvip GOPC (FIG/PIST/CAL) is a PDZ-domain scaffolding protein that regulates the trafficking of a wide array of proteins, including small GTPases, receptors, and cell surface molecules such as cadherin 23 and CFTR. In Madin-Darby Canine Kidney (MDCK) cells, we find that GOPC localizes to the Trans-Golgi Network (TGN), but not the cis or trans Golgi cisternae. There is also colocalization with the early endosome Rab GTPase Rab5 and a TGN/endosome marker Rab14, but not with Rab11, a marker of recycling endosomes. There is no localization of GOPC to the lateral membranes or tight junctions. We find that knockdown of GOPC in MDCK cells results in decreased transepithelial resistance and increased paracellular flux. This may be due to compromised trafficking of tight junction components from the TGN, as GOPC knockdown cells have decreased lateral labeling of the tight junction protein claudin-1 and decreased protein levels of claudin-2. GOPC may mediate trafficking of newly synthesized tight junction proteins from the TGN to the cell surface or recycling of these proteins from specialized endosomal compartments. Twit Text FOAVip The scaffolding protein GOPC regulates tight junction structure ????Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=25616555 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25616555 #FOAvip English Wikipedia <ref>{{Cite pmid|25616555}}</ref> The scaffolding protein GOPC regulates tight junction structure #MMPMID25616555 Lu R; Stewart L; Wilson JM Cell Tissue Res 2015[May]; 360 (2): 321-32 PMID25616555show ga GOPC (FIG/PIST/CAL) is a PDZ-domain scaffolding protein that regulates the trafficking of a wide array of proteins, including small GTPases, receptors, and cell surface molecules such as cadherin 23 and CFTR. In Madin-Darby Canine Kidney (MDCK) cells, we find that GOPC localizes to the Trans-Golgi Network (TGN), but not the cis or trans Golgi cisternae. There is also colocalization with the early endosome Rab GTPase Rab5 and a TGN/endosome marker Rab14, but not with Rab11, a marker of recycling endosomes. There is no localization of GOPC to the lateral membranes or tight junctions. We find that knockdown of GOPC in MDCK cells results in decreased transepithelial resistance and increased paracellular flux. This may be due to compromised trafficking of tight junction components from the TGN, as GOPC knockdown cells have decreased lateral labeling of the tight junction protein claudin-1 and decreased protein levels of claudin-2. GOPC may mediate trafficking of newly synthesized tight junction proteins from the TGN to the cell surface or recycling of these proteins from specialized endosomal compartments. äThe scaffolding protein GOPC regulates tight junction structure (epmc).pdf DeepDyve Pubget Overpricing