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10.1001/jamadermatol.2013.7954 http://scihub22266oqcxt.onion/10.1001/jamadermatol.2013.7954 C4414492!4414492 !24401911     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24401911 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       JAMA+Dermatol 2014 ; 150 (3 ): 254-9 Nephropedia Template TP {{tp|p=24401911 |t=2014. Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis |pdf=|usr=}}{{24401911 }} gab.com Text Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis JO: JAMA Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=24401911 #FOAvip IMPORTANCE: Atopic dermatitis (AD) is a common chronic illness of childhood. OBJECTIVE: To evaluate the association between thymic stromal lymphopoietin (TSLP) variation and the persistence of skin symptoms of AD. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study was conducted in the general community. Participants included 796 children enrolled in the Pediatric Eczema Elective Registry. EXPOSURE Evaluation of TSLP variation. MAIN OUTCOMES AND MEASURES: Self-reported outcome of whether a child's skin had no symptoms of AD and required no medications for 6 months at 6-month intervals. RESULTS: We evaluated 14 variants of TSLP. The variant rs1898671 was significantly associated with the outcome in white children (P =?.01). As measured by overlapping CIs, similar odds ratios (ORs) were noted among whites (OR, 1.72; 95% CI, 1.11-2.66) and African Americans (1.33; 0.52-3.45). Further within the subcohort of individuals with a filaggrin protein (FLG) loss-of-function mutation, those with TSLP variation were more likely to have less-persistent disease (OR, 4.92; 95% CI, 2.04-11.86). CONCLUSIONS AND RELEVANCE: The TSLP variation is associated with less persistent AD. Therefore, TSLP may be a potential therapeutic target for the treatment of AD, especially in individuals with diminished barrier function due to FLG mutations. This is an attractive hypothesis that can be tested in clinical trials. Twit Text FOAVip Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis ????JAMA Dermatol http://www.kidney.de/pget.php?&tw=1&pmid=24401911 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24401911 #FOAvip English Wikipedia <ref>{{Cite pmid|24401911 }}</ref> Thymic stromal lymphopoietin variation, filaggrin loss of function, and the persistence of atopic dermatitis #MMPMID24401911 Margolis DJ ; Kim B ; Apter AJ ; Gupta J ; Hoffstad O ; Papadopoulos M ; Mitra N JAMA Dermatol 2014[Mar]; 150 (3 ): 254-9 PMID24401911 show ga IMPORTANCE: Atopic dermatitis (AD) is a common chronic illness of childhood. OBJECTIVE: To evaluate the association between thymic stromal lymphopoietin (TSLP) variation and the persistence of skin symptoms of AD. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study was conducted in the general community. Participants included 796 children enrolled in the Pediatric Eczema Elective Registry. EXPOSURE Evaluation of TSLP variation. MAIN OUTCOMES AND MEASURES: Self-reported outcome of whether a child's skin had no symptoms of AD and required no medications for 6 months at 6-month intervals. RESULTS: We evaluated 14 variants of TSLP. The variant rs1898671 was significantly associated with the outcome in white children (P =?.01). As measured by overlapping CIs, similar odds ratios (ORs) were noted among whites (OR, 1.72; 95% CI, 1.11-2.66) and African Americans (1.33; 0.52-3.45). Further within the subcohort of individuals with a filaggrin protein (FLG) loss-of-function mutation, those with TSLP variation were more likely to have less-persistent disease (OR, 4.92; 95% CI, 2.04-11.86). CONCLUSIONS AND RELEVANCE: The TSLP variation is associated with less persistent AD. Therefore, TSLP may be a potential therapeutic target for the treatment of AD, especially in individuals with diminished barrier function due to FLG mutations. This is an attractive hypothesis that can be tested in clinical trials. |*Genetic Predisposition to Disease [MESH] |*Mutation [MESH] |Child [MESH] |Child, Preschool [MESH] |Cohort Studies [MESH] |Confidence Intervals [MESH] |Cytokines/*genetics [MESH] |Dermatitis, Atopic/epidemiology/*genetics/physiopathology [MESH] |Female [MESH] |Filaggrin Proteins [MESH] |Humans [MESH] |Intermediate Filament Proteins/*genetics [MESH] |Male [MESH] |Odds Ratio [MESH] |Polymorphism, Single Nucleotide [MESH] |Prevalence [MESH] |Prognosis [MESH] |Prospective Studies [MESH] |Recurrence [MESH] |Registries [MESH] |Risk Assessment [MESH] |Severity of Illness Index [MESH]Thymic stromal lymphopoietin variation, filaggrin loss of function, an(epmc).pdf DeepDyve Pubget Overpricing