A brief history of T cell help to B cells #MMPMID25677493
Crotty S
Nat Rev Immunol 2015[Mar]; 15 (3): 185-9 PMID25677493show ga
In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize and categorize the distinct molecules that are expressed by CD4+ T cells that constitute ?help? to B cells, and particularly the molecules expressed by T follicular helper (TFH) cells, which are the specialized providers of help to B cells.