Switch for the necroptotic permeation pore #MMPMID25295395
Shin YK; Kim J; Yang Y
Structure 2014[Oct]; 22 (10): 1374-6 PMID25295395show ga
The helical protein MLKL inserts into cell membranes and forms a permeation pore therein, resulting in cell death. The paper by Su et al. reports that helix 6 regulates the opening of the pore formed by preceding core helices.