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10.1038/ni.3036 http://scihub22266oqcxt.onion/10.1038/ni.3036 C4413902!4413902!25401424     free     free     free       Nat+Immunol 2015 ; 16 (1): 118-28 Nephropedia Template TP {{tp|p=25401424|t=2015. TLR7 induces anergy in human CD4+ T cells |pdf=|usr=}}{{25401424}} gab.com Text TLR7 induces anergy in human CD4+ T cells JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25401424 #FOAvip Pattern recognition of microbes by Toll-like receptors (TLR) is critical for innate immune system activation. Although TLRs are expressed in human CD4+ T cells, their function is not well understood. Here we demonstrate that engaging TLR7 in CD4+ T cells induces intracellular calcium flux with activation of an NFATc2-dependent anergic gene expression program and T cell non-responsiveness. As chronic infections with RNA viruses such as HIV-1 induce profound CD4+ T cell dysfunction, we examined the role of TLR7-induced anergy in HIV-1 infection. TLR7 gene silencing markedly decreases the frequency of HIV-1-infected CD4+ T cells and restores cell responsiveness in those HIV-1+ CD4+ T cells. These results elucidate a previously unknown function for microbial pattern recognition receptors to down-regulate immune responses. Twit Text FOAVip TLR7 induces anergy in human CD4+ T cells ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25401424 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25401424 #FOAvip English Wikipedia <ref>{{Cite pmid|25401424}}</ref> TLR7 induces anergy in human CD4+ T cells #MMPMID25401424 Dominguez-Villar M; Gautron AS; de Marcken M; Keller MJ; Hafler DA Nat Immunol 2015[Jan]; 16 (1): 118-28 PMID25401424show ga Pattern recognition of microbes by Toll-like receptors (TLR) is critical for innate immune system activation. Although TLRs are expressed in human CD4+ T cells, their function is not well understood. Here we demonstrate that engaging TLR7 in CD4+ T cells induces intracellular calcium flux with activation of an NFATc2-dependent anergic gene expression program and T cell non-responsiveness. As chronic infections with RNA viruses such as HIV-1 induce profound CD4+ T cell dysfunction, we examined the role of TLR7-induced anergy in HIV-1 infection. TLR7 gene silencing markedly decreases the frequency of HIV-1-infected CD4+ T cells and restores cell responsiveness in those HIV-1+ CD4+ T cells. These results elucidate a previously unknown function for microbial pattern recognition receptors to down-regulate immune responses. äTLR7 induces anergy in human CD4+ T cells (epmc).pdf DeepDyve Pubget Overpricing