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10.1126/science.aaa4080 http://scihub22266oqcxt.onion/10.1126/science.aaa4080 C4413427!4413427!25814576     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2015 ; 347 (6229): 1441-6 Nephropedia Template TP {{tp|p=25814576|t=2015. The structure of the dynactin complex and its interaction with dynein |pdf=|usr=}}{{25814576}} gab.com Text The structure of the dynactin complex and its interaction with dynein JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=25814576 #FOAvip Dynactin is an essential cofactor for the microtubule motor cytoplasmic dynein-1. We report the structure of the 23 subunit dynactin complex by cryo-electron microscopy to 4.0Å. Our reconstruction reveals how dynactin is built around a filament containing eight copies of the actin related protein Arp1 and one of ?-actin. Capped at each end by distinct protein complexes, the length of the filament is defined by elongated peptides that emerge from the ?-helical shoulder domain. A further 8.2Å structure of the complex between dynein, dynactin and the motility inducing cargo adaptor Bicaudal-D2 shows how the translational symmetry of the dynein tail matches that of the dynactin filament. The Bicaudal-D2 coiled coil runs between dynein and dynactin to stabilize the mutually dependent interactions between all three components. Twit Text FOAVip The structure of the dynactin complex and its interaction with dynein ????Science http://www.kidney.de/pget.php?&tw=1&pmid=25814576 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25814576 #FOAvip English Wikipedia <ref>{{Cite pmid|25814576}}</ref> The structure of the dynactin complex and its interaction with dynein #MMPMID25814576 Urnavicius L; Zhang K; Diamant AG; Motz C; Schlager MA; Yu M; Patel NA; Robinson CV; Carter AP Science 2015[Mar]; 347 (6229): 1441-6 PMID25814576show ga Dynactin is an essential cofactor for the microtubule motor cytoplasmic dynein-1. We report the structure of the 23 subunit dynactin complex by cryo-electron microscopy to 4.0Å. Our reconstruction reveals how dynactin is built around a filament containing eight copies of the actin related protein Arp1 and one of ?-actin. Capped at each end by distinct protein complexes, the length of the filament is defined by elongated peptides that emerge from the ?-helical shoulder domain. A further 8.2Å structure of the complex between dynein, dynactin and the motility inducing cargo adaptor Bicaudal-D2 shows how the translational symmetry of the dynein tail matches that of the dynactin filament. The Bicaudal-D2 coiled coil runs between dynein and dynactin to stabilize the mutually dependent interactions between all three components. äThe structure of the dynactin complex and its interaction with dynein (epmc).pdf DeepDyve Pubget Overpricing