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10.1073/pnas.1420707112 http://scihub22266oqcxt.onion/10.1073/pnas.1420707112 C4413347!4413347 !25848056     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25848056 &cmd=llinks): Failed to open stream: HTTP request failed! 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NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation |pdf=|usr=}}{{25848056 }} gab.com Text NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25848056 #FOAvip Ionizing radiation (IR) causes not only acute tissue damage, but also late effects in several cell generations after the initial exposure. The thyroid gland is one of the most sensitive organs to the carcinogenic effects of IR, and we have recently highlighted that an oxidative stress is responsible for the chromosomal rearrangements found in radio-induced papillary thyroid carcinoma. Using both a human thyroid cell line and primary thyrocytes, we investigated the mechanism by which IR induces the generation of reactive oxygen species (ROS) several days after irradiation. We focused on NADPH oxidases, which are specialized ROS-generating enzymes known as NOX/DUOX. Our results show that IR induces delayed NADPH oxidase DUOX1-dependent H2O2 production in a dose-dependent manner, which is sustained for several days. We report that p38 MAPK, activated after IR, increased DUOX1 via IL-13 expression, leading to persistent DNA damage and growth arrest. Pretreatment of cells with catalase, a scavenger of H2O2, or DUOX1 down-regulation by siRNA abrogated IR-induced DNA damage. Analysis of human thyroid tissues showed that DUOX1 is elevated not only in human radio-induced thyroid tumors, but also in sporadic thyroid tumors. Taken together, our data reveal a key role of DUOX1-dependent H2O2 production in long-term persistent radio-induced DNA damage. Our data also show that DUOX1-dependent H2O2 production, which induces DNA double-strand breaks, can cause genomic instability and promote the generation of neoplastic cells through its mutagenic effect. Twit Text FOAVip NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25848056 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25848056 #FOAvip English Wikipedia <ref>{{Cite pmid|25848056 }}</ref> NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation #MMPMID25848056 Ameziane-El-Hassani R ; Talbot M ; de Souza Dos Santos MC ; Al Ghuzlan A ; Hartl D ; Bidart JM ; De Deken X ; Miot F ; Diallo I ; de Vathaire F ; Schlumberger M ; Dupuy C Proc Natl Acad Sci U S A 2015[Apr]; 112 (16 ): 5051-6 PMID25848056 show ga Ionizing radiation (IR) causes not only acute tissue damage, but also late effects in several cell generations after the initial exposure. The thyroid gland is one of the most sensitive organs to the carcinogenic effects of IR, and we have recently highlighted that an oxidative stress is responsible for the chromosomal rearrangements found in radio-induced papillary thyroid carcinoma. Using both a human thyroid cell line and primary thyrocytes, we investigated the mechanism by which IR induces the generation of reactive oxygen species (ROS) several days after irradiation. We focused on NADPH oxidases, which are specialized ROS-generating enzymes known as NOX/DUOX. Our results show that IR induces delayed NADPH oxidase DUOX1-dependent H2O2 production in a dose-dependent manner, which is sustained for several days. We report that p38 MAPK, activated after IR, increased DUOX1 via IL-13 expression, leading to persistent DNA damage and growth arrest. Pretreatment of cells with catalase, a scavenger of H2O2, or DUOX1 down-regulation by siRNA abrogated IR-induced DNA damage. Analysis of human thyroid tissues showed that DUOX1 is elevated not only in human radio-induced thyroid tumors, but also in sporadic thyroid tumors. Taken together, our data reveal a key role of DUOX1-dependent H2O2 production in long-term persistent radio-induced DNA damage. Our data also show that DUOX1-dependent H2O2 production, which induces DNA double-strand breaks, can cause genomic instability and promote the generation of neoplastic cells through its mutagenic effect. |*Gamma Rays [MESH] |Cell Line [MESH] |DNA Damage [MESH] |Dual Oxidases [MESH] |Extracellular Space/metabolism/radiation effects [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Hydrogen Peroxide/metabolism [MESH] |Interleukin-13/genetics/metabolism [MESH] |NADPH Oxidases/genetics/*metabolism [MESH] |Oxidative Stress/*radiation effects [MESH] |Thyroid Gland/enzymology/pathology [MESH] |Thyroid Neoplasms/enzymology/genetics/pathology [MESH]NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress(epmc).pdf DeepDyve Pubget Overpricing