Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25864811
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Iran+Biomed+J
2015 ; 19
(2
): 76-81
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Comparative assessment of neutrophil gelatinase-associated lipocalin (NGAL) and
cystatin C as early biomarkers for early detection of renal failure in patients
with hypertension
#MMPMID25864811
Gharishvandi F
; Kazerouni F
; Ghanei E
; Rahimipour A
; Nasiri M
Iran Biomed J
2015[]; 19
(2
): 76-81
PMID25864811
show ga
BACKGROUND: Hypertension is one the most common causes of chronic kidney disease
(CKD). One of the major concerns in hypertensive patients is early detection of
renal disorders. In the past, serum creatinine (Scr) concentration was used as a
marker of kidney function, but it proffers a late reflection of reduced
glomerular filtration rate. Cystatin C and neutrophil gelatinase-associated
lipocalin (NGAL) have been recently proven to be useful for quantification of
CKD. Therefore, we compared the diagnostic value of NGAL with cystatin C and
creatinine to evaluate kidney function in hypertensive patients. METHODS: In this
study, 42 hypertensive patients and 30 healthy volunteers were recruited. Serum
cystatin C (Scys C) and plasma NGAL were measured using ELISA method. Creatinine,
urea, hemoglobin, fibrinogen, and C-reactive protein were measured according to
the routine methods. Estimated glomerular filtration rate (eGFR) was considered
as the gold standard method (cut-off value of < 78 ml/min/1.73 mē. RESULTS: In
the patient group, plasma NGAL, cystatin C, and creatinine were all significantly
correlated with eGFR, and plasma NGAL correlated best with eGFR.
Receiver-operating characteristics analysis indicated that plasma NGAL was a
better indicator than creatinine and cystatin C for predicting a GFR < 78
ml/min/1.73 m2. The sensitivity and specificity for NGAL were 96% and 100%, for
cystatin C were 92% and 60% and for creatinine were 76% and 47%, respectively.
CONCLUSION: Plasma NGAL demonstrated a higher diagnostic value to detect kidney
impairment in the early stages of CKD as compared to Scys C and Scr in
hypertensive patients.