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10.1523/JNEUROSCI.4926-14.2015 http://scihub22266oqcxt.onion/10.1523/JNEUROSCI.4926-14.2015 C4412896!4412896 !25926454     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25926454 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Neurosci 2015 ; 35 (17 ): 6770-85 Nephropedia Template TP {{tp|p=25926454 |t=2015. Anti-Ganglioside Antibodies Induce Nodal and Axonal Injury via Fc? Receptor-Mediated Inflammation |pdf=|usr=}}{{25926454 }} gab.com Text Anti-Ganglioside Antibodies Induce Nodal and Axonal Injury via Fc Receptor-Mediated Inflammation JO: J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25926454 #FOAvip Guillain-Barré syndrome (GBS) is a postinfectious autoimmune neuropathy and anti-ganglioside antibodies (Abs) are strongly associated with this disorder. Several studies have implied that specific anti-ganglioside Abs induce neuropathy in patients with axonal forms of GBS. To study the mechanisms of anti-ganglioside Abs-induced neuropathy, we established a new passive transfer mouse model by L5 spinal nerve transection (L5SNT; modified Chung's model) and systemic administration of anti-ganglioside Abs. L5SNT causes degeneration of a small proportion of fibers that constitute sciatic nerve and its branches, but importantly breaks the blood-nerve barrier, which allows access to circulating Abs and inflammatory cells. Our studies indicate that, in this mouse model, anti-ganglioside Abs induce sequential nodal and axonal injury of intact myelinated nerve fibers, recapitulating pathologic features of human disease. Notably, our results showed that immune complex formation and the activating Fc gamma receptors (Fc?Rs) were involved in the anti-ganglioside Abs-mediated nodal and axonal injury in this model. These studies provide new evidence that the activating Fc?Rs-mediated inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact nerve fibers) in GBS. Twit Text FOAVip Anti-Ganglioside Antibodies Induce Nodal and Axonal Injury via Fc Receptor-Mediated Inflammation ????J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25926454 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25926454 #FOAvip English Wikipedia <ref>{{Cite pmid|25926454 }}</ref> Anti-Ganglioside Antibodies Induce Nodal and Axonal Injury via Fc? Receptor-Mediated Inflammation #MMPMID25926454 He L ; Zhang G ; Liu W ; Gao T ; Sheikh KA J Neurosci 2015[Apr]; 35 (17 ): 6770-85 PMID25926454 show ga Guillain-Barré syndrome (GBS) is a postinfectious autoimmune neuropathy and anti-ganglioside antibodies (Abs) are strongly associated with this disorder. Several studies have implied that specific anti-ganglioside Abs induce neuropathy in patients with axonal forms of GBS. To study the mechanisms of anti-ganglioside Abs-induced neuropathy, we established a new passive transfer mouse model by L5 spinal nerve transection (L5SNT; modified Chung's model) and systemic administration of anti-ganglioside Abs. L5SNT causes degeneration of a small proportion of fibers that constitute sciatic nerve and its branches, but importantly breaks the blood-nerve barrier, which allows access to circulating Abs and inflammatory cells. Our studies indicate that, in this mouse model, anti-ganglioside Abs induce sequential nodal and axonal injury of intact myelinated nerve fibers, recapitulating pathologic features of human disease. Notably, our results showed that immune complex formation and the activating Fc gamma receptors (Fc?Rs) were involved in the anti-ganglioside Abs-mediated nodal and axonal injury in this model. These studies provide new evidence that the activating Fc?Rs-mediated inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact nerve fibers) in GBS. |Action Potentials/drug effects/physiology [MESH] |Animals [MESH] |Antibodies, Monoclonal/*adverse effects [MESH] |Complement C5/genetics [MESH] |Disease Models, Animal [MESH] |Female [MESH] |Gangliosides/*immunology [MESH] |Humans [MESH] |Hyperalgesia/etiology [MESH] |Macrophage Colony-Stimulating Factor/genetics [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |N-Acetylgalactosaminyltransferases/genetics [MESH] |Neural Conduction/drug effects/genetics [MESH] |Neurogenic Inflammation/*etiology [MESH] |Pain Threshold/drug effects [MESH] |Peripheral Nerve Injuries/blood/*complications/*etiology/genetics [MESH] |Receptors, IgG/genetics/*metabolism [MESH] |Sciatic Nerve/pathology/physiopathology [MESH]Anti-Ganglioside Antibodies Induce Nodal and Axonal Injury via Fc? 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