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10.1080/08927022.2014.896462 http://scihub22266oqcxt.onion/10.1080/08927022.2014.896462 C4412168!4412168!25931676     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Simul 2014 ; 40 (10-11): 821-9 Nephropedia Template TP {{tp|p=25931676|t=2014. Pentameric Ligand-gated Ion Channels : Insights from Computation |pdf=|usr=}}{{25931676}} gab.com Text Pentameric Ligand-gated Ion Channels : Insights from Computation JO: Mol Simul http://www.kidney.de/pget.php?&tw=1&pmid=25931676 #FOAvip Pentameric ligand-gated ion channels (pLGICs) conduct upon the binding of an agonist and are fundamental to neurotransmission. New insights into the complex mechanisms underlying pLGIC gating, ion selectivity, and modulation have recently been gained via a series of crystal structures in prokaryotes and C .elegans, as well as computational studies relying on these structures. Here we review contributions from a variety of computational approaches, including normal mode analysis, automated docking, and fully atomistic molecular dynamics simulation. Examples from our own research, particularly concerning interactions with general anesthetics and lipids, are used to illustrate predictive results complementary to crystallographic studies. Twit Text FOAVip Pentameric Ligand-gated Ion Channels : Insights from Computation ????Mol Simul http://www.kidney.de/pget.php?&tw=1&pmid=25931676 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25931676 #FOAvip English Wikipedia <ref>{{Cite pmid|25931676}}</ref> Pentameric Ligand-gated Ion Channels : Insights from Computation #MMPMID25931676 Salari R; Murlidaran S; Brannigan G Mol Simul 2014[Apr]; 40 (10-11): 821-9 PMID25931676show ga Pentameric ligand-gated ion channels (pLGICs) conduct upon the binding of an agonist and are fundamental to neurotransmission. New insights into the complex mechanisms underlying pLGIC gating, ion selectivity, and modulation have recently been gained via a series of crystal structures in prokaryotes and C .elegans, as well as computational studies relying on these structures. Here we review contributions from a variety of computational approaches, including normal mode analysis, automated docking, and fully atomistic molecular dynamics simulation. Examples from our own research, particularly concerning interactions with general anesthetics and lipids, are used to illustrate predictive results complementary to crystallographic studies. äPentameric Ligand-gated Ion Channels : Insights from Computation (epmc).pdf DeepDyve Pubget Overpricing