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10.1186/s13045-015-0133-5 http://scihub22266oqcxt.onion/10.1186/s13045-015-0133-5 C4412036!4412036!25895683     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Hematol+Oncol 2015 ; 8 (ä): ä Nephropedia Template TP {{tp|p=25895683|t=2015. piRNA involvement in genome stability and human cancer |pdf=|usr=}}{{25895683}} gab.com Text piRNA involvement in genome stability and human cancer JO: J Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25895683 #FOAvip PIWI-interacting RNAs (piRNAs) are a large family of small, single-stranded, non-coding RNAs present throughout the animal kingdom. They form complexes with several members of the PIWI clade of Argonaute proteins and carry out regulatory functions. Their best established biological role is the inhibition of transposon mobilization, which they enforce both at the transcriptional level, through regulation of heterochromatin formation, and by promoting transcript degradation. In this capacity, piRNAs and PIWI proteins are at the heart of the germline cells? efforts to preserve genome integrity. Additional regulatory roles of piRNAs and PIWI proteins in gene expression are becoming increasingly apparent.PIWI proteins and piRNAs are often detected in human cancers deriving from germline cells as well as somatic tissues. Their detection in cancer correlates with poorer clinical outcomes, suggesting that they play a functional role in the biology of cancer. Nonetheless, the currently available information, while highly suggestive, is still not sufficient to entirely discriminate between a ?passenger? role for the ectopic expression of piRNAs and PIWI proteins in cancer from a ?driver? role in the pathogenesis of these diseases. In this article, we review some of the key available evidence for the role of piRNAs and PIWI in human cancer and discuss ways in which our understanding of their functions may be improved. Twit Text FOAVip piRNA involvement in genome stability and human cancer ????J Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25895683 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25895683 #FOAvip English Wikipedia <ref>{{Cite pmid|25895683}}</ref> piRNA involvement in genome stability and human cancer #MMPMID25895683 Moyano M; Stefani G J Hematol Oncol 2015[]; 8 (ä): ä PMID25895683show ga PIWI-interacting RNAs (piRNAs) are a large family of small, single-stranded, non-coding RNAs present throughout the animal kingdom. They form complexes with several members of the PIWI clade of Argonaute proteins and carry out regulatory functions. Their best established biological role is the inhibition of transposon mobilization, which they enforce both at the transcriptional level, through regulation of heterochromatin formation, and by promoting transcript degradation. In this capacity, piRNAs and PIWI proteins are at the heart of the germline cells? efforts to preserve genome integrity. Additional regulatory roles of piRNAs and PIWI proteins in gene expression are becoming increasingly apparent.PIWI proteins and piRNAs are often detected in human cancers deriving from germline cells as well as somatic tissues. Their detection in cancer correlates with poorer clinical outcomes, suggesting that they play a functional role in the biology of cancer. Nonetheless, the currently available information, while highly suggestive, is still not sufficient to entirely discriminate between a ?passenger? role for the ectopic expression of piRNAs and PIWI proteins in cancer from a ?driver? role in the pathogenesis of these diseases. In this article, we review some of the key available evidence for the role of piRNAs and PIWI in human cancer and discuss ways in which our understanding of their functions may be improved. äpiRNA involvement in genome stability and human cancer (epmc).pdf DeepDyve Pubget Overpricing