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10.1093/bioinformatics/btu833 http://scihub22266oqcxt.onion/10.1093/bioinformatics/btu833 C4410656!4410656!25527098     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25527098&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioinformatics 2015 ; 31 (9): 1366-74 Nephropedia Template TP {{tp|p=25527098|t=2015. MicroRNA modules prefer to bind weak and unconventional target sites |pdf=|usr=}}{{25527098}} gab.com Text MicroRNA modules prefer to bind weak and unconventional target sites JO: Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=25527098 #FOAvip Motivation: MicroRNAs (miRNAs) play critical roles in gene regulation. Although it is well known that multiple miRNAs may work as miRNA modules to synergistically regulate common target mRNAs, the understanding of miRNA modules is still in its infancy.Results: We employed the recently generated high throughput experimental data to study miRNA modules. We predicted 181 miRNA modules and 306 potential miRNA modules. We observed that the target sites of these predicted modules were in general weaker compared with those not bound by miRNA modules. We also discovered that miRNAs in predicted modules preferred to bind unconventional target sites rather than canonical sites. Surprisingly, contrary to a previous study, we found that most adjacent miRNA target sites from the same miRNA modules were not within the range of 10?130 nucleotides. Interestingly, the distance of target sites bound by miRNAs in the same modules was shorter when miRNA modules bound unconventional instead of canonical sites. Our study shed new light on miRNA binding and miRNA target sites, which will likely advance our understanding of miRNA regulation.Availability and implementation: The software miRModule can be freely downloaded at http://hulab.ucf.edu/research/projects/miRNA/miRModule.Supplementary information:Supplementary data are available at Bioinformatics online.Contact:haihu@cs.ucf.edu or xiaoman@mail.ucf.edu. Twit Text FOAVip MicroRNA modules prefer to bind weak and unconventional target sites ????Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=25527098 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25527098 #FOAvip English Wikipedia <ref>{{Cite pmid|25527098}}</ref> MicroRNA modules prefer to bind weak and unconventional target sites #MMPMID25527098 Ding J; Li X; Hu H Bioinformatics 2015[May]; 31 (9): 1366-74 PMID25527098show ga Motivation: MicroRNAs (miRNAs) play critical roles in gene regulation. Although it is well known that multiple miRNAs may work as miRNA modules to synergistically regulate common target mRNAs, the understanding of miRNA modules is still in its infancy.Results: We employed the recently generated high throughput experimental data to study miRNA modules. We predicted 181 miRNA modules and 306 potential miRNA modules. We observed that the target sites of these predicted modules were in general weaker compared with those not bound by miRNA modules. We also discovered that miRNAs in predicted modules preferred to bind unconventional target sites rather than canonical sites. Surprisingly, contrary to a previous study, we found that most adjacent miRNA target sites from the same miRNA modules were not within the range of 10?130 nucleotides. Interestingly, the distance of target sites bound by miRNAs in the same modules was shorter when miRNA modules bound unconventional instead of canonical sites. Our study shed new light on miRNA binding and miRNA target sites, which will likely advance our understanding of miRNA regulation.Availability and implementation: The software miRModule can be freely downloaded at http://hulab.ucf.edu/research/projects/miRNA/miRModule.Supplementary information:Supplementary data are available at Bioinformatics online.Contact:haihu@cs.ucf.edu or xiaoman@mail.ucf.edu. äMicroRNA modules prefer to bind weak and unconventional target sites (epmc).pdf DeepDyve Pubget Overpricing