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10.1161/CIRCRESAHA.116.303518 http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.116.303518 C4410432!4410432 !25908728     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25908728 &cmd=llinks): Failed to open stream: HTTP request failed! 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The genetic basis of peripheral arterial disease: current knowledge, challenges, and future directions |pdf=|usr=}}{{25908728 }} gab.com Text The genetic basis of peripheral arterial disease: current knowledge, challenges, and future directions JO: Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=25908728 #FOAvip Several risk factors for atherosclerotic peripheral arterial disease (PAD), such as dyslipidemia, diabetes mellitus, and hypertension, are heritable. However, predisposition to PAD may be influenced by genetic variants acting independently of these risk factors. Identification of such genetic variants will provide insights into underlying pathophysiologic mechanisms and facilitate the development of novel diagnostic and therapeutic approaches. In contrast to coronary heart disease, relatively few genetic variants that influence susceptibility to PAD have been discovered. This may be, in part, because of greater clinical and genetic heterogeneity in PAD. In this review, we (1) provide an update on the current state of knowledge about the genetic basis of PAD, including results of family studies and candidate gene, linkage as well as genome-wide association studies; (2) highlight the challenges in investigating the genetic basis of PAD and possible strategies to overcome these challenges; and (3) discuss the potential of genome sequencing, RNA sequencing, differential gene expression, epigenetic profiling, and systems biology in increasing our understanding of the molecular genetics of PAD. Twit Text FOAVip The genetic basis of peripheral arterial disease: current knowledge, challenges, and future directions ????Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=25908728 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25908728 #FOAvip English Wikipedia <ref>{{Cite pmid|25908728 }}</ref> The genetic basis of peripheral arterial disease: current knowledge, challenges, and future directions #MMPMID25908728 Kullo IJ ; Leeper NJ Circ Res 2015[Apr]; 116 (9 ): 1551-60 PMID25908728 show ga Several risk factors for atherosclerotic peripheral arterial disease (PAD), such as dyslipidemia, diabetes mellitus, and hypertension, are heritable. However, predisposition to PAD may be influenced by genetic variants acting independently of these risk factors. Identification of such genetic variants will provide insights into underlying pathophysiologic mechanisms and facilitate the development of novel diagnostic and therapeutic approaches. In contrast to coronary heart disease, relatively few genetic variants that influence susceptibility to PAD have been discovered. This may be, in part, because of greater clinical and genetic heterogeneity in PAD. In this review, we (1) provide an update on the current state of knowledge about the genetic basis of PAD, including results of family studies and candidate gene, linkage as well as genome-wide association studies; (2) highlight the challenges in investigating the genetic basis of PAD and possible strategies to overcome these challenges; and (3) discuss the potential of genome sequencing, RNA sequencing, differential gene expression, epigenetic profiling, and systems biology in increasing our understanding of the molecular genetics of PAD. |*Polymorphism, Single Nucleotide [MESH] |Epigenesis, Genetic [MESH] |Forecasting [MESH] |Gene Expression Profiling/methods/trends [MESH] |Gene-Environment Interaction [MESH] |Genetic Predisposition to Disease/*genetics [MESH] |Genome-Wide Association Study/*methods/trends [MESH] |High-Throughput Nucleotide Sequencing/methods/trends [MESH] |Humans [MESH]The genetic basis of peripheral arterial disease: current knowledge, c(epmc).pdf DeepDyve Pubget Overpricing