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10.1038/ncomms7956 http://scihub22266oqcxt.onion/10.1038/ncomms7956 C4410277!4410277 !25907800     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25907800 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25907800 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2015 ; 6 (ä): 6956 Nephropedia Template TP {{tp|p=25907800 |t=2015. Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis |pdf=|usr=}}{{25907800 }} gab.com Text Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25907800 #FOAvip Gut-associated inflammation plays a crucial role in the progression of colon cancer. Here, we identify a novel pathogen-host interaction that promotes gut inflammation and the development of colon cancer. We find that enteropathogenic bacteria-secreted particles (ET-BSPs) stimulate intestinal epithelium to produce IDENs (intestinal mucosa-derived exosome-like nanoparticles) containing elevated levels of sphingosine-1-phosphate, CCL20 and prostaglandin E2 (PGE2). CCL20 and PGE2 are required for the recruitment and proliferation, respectively, of Th17 cells, and these processes also involve the MyD88-mediated pathway. By influencing the recruitment and proliferation of Th17 cells in the intestine, IDENs promote colon cancer. We demonstrate the biological effect of sphingosine-1-phosphate contained in IDENs on tumour growth in spontaneous and transplanted colon cancer mouse models. These findings provide deeper insights into how host-microbe relationships are mediated by particles secreted from both bacterial and host cells. Twit Text FOAVip Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25907800 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25907800 #FOAvip English Wikipedia <ref>{{Cite pmid|25907800 }}</ref> Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis #MMPMID25907800 Deng Z ; Mu J ; Tseng M ; Wattenberg B ; Zhuang X ; Egilmez NK ; Wang Q ; Zhang L ; Norris J ; Guo H ; Yan J ; Haribabu B ; Miller D ; Zhang HG Nat Commun 2015[Apr]; 6 (ä): 6956 PMID25907800 show ga Gut-associated inflammation plays a crucial role in the progression of colon cancer. Here, we identify a novel pathogen-host interaction that promotes gut inflammation and the development of colon cancer. We find that enteropathogenic bacteria-secreted particles (ET-BSPs) stimulate intestinal epithelium to produce IDENs (intestinal mucosa-derived exosome-like nanoparticles) containing elevated levels of sphingosine-1-phosphate, CCL20 and prostaglandin E2 (PGE2). CCL20 and PGE2 are required for the recruitment and proliferation, respectively, of Th17 cells, and these processes also involve the MyD88-mediated pathway. By influencing the recruitment and proliferation of Th17 cells in the intestine, IDENs promote colon cancer. We demonstrate the biological effect of sphingosine-1-phosphate contained in IDENs on tumour growth in spontaneous and transplanted colon cancer mouse models. These findings provide deeper insights into how host-microbe relationships are mediated by particles secreted from both bacterial and host cells. |Adenocarcinoma/etiology/*immunology/pathology [MESH] |Animals [MESH] |Azoxymethane/toxicity [MESH] |Bacteroides fragilis/*immunology/metabolism [MESH] |Blotting, Western [MESH] |Carcinogenesis/*immunology [MESH] |Carcinogens/toxicity [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Chemokine CCL20/genetics/immunology [MESH] |Colitis/chemically induced/complications/*immunology [MESH] |Colonic Neoplasms/etiology/*immunology/pathology [MESH] |Dextran Sulfate/toxicity [MESH] |Dinoprostone/genetics/immunology [MESH] |Disease Models, Animal [MESH] |Enterobacteriaceae/*immunology/metabolism [MESH] |Exosomes/*immunology [MESH] |Immunohistochemistry [MESH] |In Situ Hybridization, Fluorescence [MESH] |Inflammation [MESH] |Intestinal Mucosa/*immunology [MESH] |Lysophospholipids/*immunology [MESH] |Mice [MESH] |Myeloid Differentiation Factor 88/genetics/immunology [MESH] |Nanoparticles [MESH] |Neoplasm Transplantation [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Sphingosine/*analogs & derivatives/immunology [MESH]Enterobacteria-secreted particles induce production of exosome-like (epmc).pdf DeepDyve Pubget Overpricing