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10.1016/j.semcdb.2015.02.014 http://scihub22266oqcxt.onion/10.1016/j.semcdb.2015.02.014 C4410082!4410082!25725369     free     free     free       Semin+Cell+Dev+Biol 2015 ; 39 (ä): 3-11 Nephropedia Template TP {{tp|p=25725369|t=2015. Cell Death in Genome Evolution |pdf=|usr=}}{{25725369}} gab.com Text Cell Death in Genome Evolution JO: Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=25725369 #FOAvip Inappropriate survival of abnormal cells underlies tumorigenesis. Most discoveries about programmed cell death have come from studying model organisms. Revisiting the experimental contexts that inspired these discoveries helps explain confounding biases that inevitably accompany such discoveries. Amending early biases has added a newcomer to the collection of cell death models. Analysis of gene-dependent death in yeast revealed the surprising influence of single gene mutations on subsequent eukaryotic genome evolution. Similar events may influence the selection for mutations during early tumorigenesis. The possibility that an early random mutation might drive the selection for a cancer driver mutation is conceivable but difficult to demonstrate. This was tested in yeast, revealing that mutation of almost any gene appears to specify the selection for a new second mutation. Some human tumors contain pairs of mutant genes homologous to co-occurring mutant genes in yeast. Here we consider how yeast again provide novel insights into tumorigenesis. Twit Text FOAVip Cell Death in Genome Evolution ????Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=25725369 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25725369 #FOAvip English Wikipedia <ref>{{Cite pmid|25725369}}</ref> Cell Death in Genome Evolution #MMPMID25725369 Teng X; Hardwick JM Semin Cell Dev Biol 2015[Mar]; 39 (ä): 3-11 PMID25725369show ga Inappropriate survival of abnormal cells underlies tumorigenesis. Most discoveries about programmed cell death have come from studying model organisms. Revisiting the experimental contexts that inspired these discoveries helps explain confounding biases that inevitably accompany such discoveries. Amending early biases has added a newcomer to the collection of cell death models. Analysis of gene-dependent death in yeast revealed the surprising influence of single gene mutations on subsequent eukaryotic genome evolution. Similar events may influence the selection for mutations during early tumorigenesis. The possibility that an early random mutation might drive the selection for a cancer driver mutation is conceivable but difficult to demonstrate. This was tested in yeast, revealing that mutation of almost any gene appears to specify the selection for a new second mutation. Some human tumors contain pairs of mutant genes homologous to co-occurring mutant genes in yeast. Here we consider how yeast again provide novel insights into tumorigenesis. äCell Death in Genome Evolution (epmc).pdf DeepDyve Pubget Overpricing