Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3109/08916934.2014.921811 http://scihub22266oqcxt.onion/10.3109/08916934.2014.921811 C4410020!4410020!24916843     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autoimmunity 2014 ; 47 (8): 487-93 Nephropedia Template TP {{tp|p=24916843|t=2014. The Complex Role of DNA, Histones and HMGB1 in the Pathogenesis of SLE |pdf=|usr=}}{{24916843}} gab.com Text The Complex Role of DNA, Histones and HMGB1 in the Pathogenesis of SLE JO: Autoimmunity http://www.kidney.de/pget.php?&tw=1&pmid=24916843 #FOAvip Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antinuclear antibodies (ANA) in association with protean clinic manifestations. ANA can bind to nuclear molecules, most prominently DNA and histones in nucleosomes, to form complexes to promote pathogenesis. Because of the intrinsic immunological activity of the nuclear components, these complexes can amplify responses by interacting with diverse pattern recognition receptors and internal sensing systems. Among molecules associated with nucleosomal components, HMGB1, a non-histone protein, can emanate from activated and dying cells; HMGB1?s immune activity is determined by post-translational modifications, redox state and binding to other immune mediators. Although ANAs form complexes that deposit in the kidney or induce type 1 interferon, ANAs may also block immune activity. Together, these studies highlight the importance of complexes in the pathogenesis of lupus and their role as antigens, immunogens and adjuvants. Twit Text FOAVip The Complex Role of DNA, Histones and HMGB1 in the Pathogenesis of SLE ????Autoimmunity http://www.kidney.de/pget.php?&tw=1&pmid=24916843 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24916843 #FOAvip English Wikipedia <ref>{{Cite pmid|24916843}}</ref> The Complex Role of DNA, Histones and HMGB1 in the Pathogenesis of SLE #MMPMID24916843 Pisetsky DS Autoimmunity 2014[Dec]; 47 (8): 487-93 PMID24916843show ga Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antinuclear antibodies (ANA) in association with protean clinic manifestations. ANA can bind to nuclear molecules, most prominently DNA and histones in nucleosomes, to form complexes to promote pathogenesis. Because of the intrinsic immunological activity of the nuclear components, these complexes can amplify responses by interacting with diverse pattern recognition receptors and internal sensing systems. Among molecules associated with nucleosomal components, HMGB1, a non-histone protein, can emanate from activated and dying cells; HMGB1?s immune activity is determined by post-translational modifications, redox state and binding to other immune mediators. Although ANAs form complexes that deposit in the kidney or induce type 1 interferon, ANAs may also block immune activity. Together, these studies highlight the importance of complexes in the pathogenesis of lupus and their role as antigens, immunogens and adjuvants. äThe Complex Role of DNA, Histones and HMGB1 in the Pathogenesis of SLE(epmc).pdf DeepDyve Pubget Overpricing