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10.1111/cas.12615 http://scihub22266oqcxt.onion/10.1111/cas.12615 C4409892!4409892 !25613547     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25613547 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Sci 2015 ; 106 (4 ): 466-74 Nephropedia Template TP {{tp|p=25613547 |t=2015. Spread of tumor microenvironment contributes to colonic obstruction through subperitoneal fibroblast activation in colon cancer |pdf=|usr=}}{{25613547 }} gab.com Text Spread of tumor microenvironment contributes to colonic obstruction through subperitoneal fibroblast activation in colon cancer JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=25613547 #FOAvip We evaluated the influence of the cancer microenvironment formed by peritoneal invasion (CMPI) on clinical findings in colon cancer patients. In addition to the association with poor prognosis, we discovered a relationship with bowel obstruction. Detailed analysis revealed that clinical findings related to bowel obstruction occurred more frequently in patients with an elevated type tumor, which had peritoneal elastic laminal elevation to the tumor surface, compared to those with non-elevated type tumors among those with elastic laminal invasion (ELI). Lateral tumor spread and increase of tumor annularity rate in ELI-positive elevated type cases suggested the morphological progression from ELI-positive non-elevated type to elevated type. In addition, ?-smooth muscle actin expression was the highest in ELI-positive elevated type, and prominent expressions were found not only in the deep tumor area but also in the shallow tumor area. Furthermore, contraction assays revealed the robust contractile ability of subperitoneal fibroblasts stimulated by cancer cell-conditioned medium. Our findings suggest that CMPI spread into the luminal side of the colonic wall along with tumor progression, which caused bowel obstruction through the activation of subperitoneal fibroblasts. However, although the clinical outcome was not different between the two types, the clinical findings were affected by the spread of CMPI. We are the first to explore how the alteration of the tumor-promoting microenvironment, along with tumor progression, contributes to the development of clinical findings. Twit Text FOAVip Spread of tumor microenvironment contributes to colonic obstruction through subperitoneal fibroblast activation in colon cancer ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=25613547 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25613547 #FOAvip English Wikipedia <ref>{{Cite pmid|25613547 }}</ref> Spread of tumor microenvironment contributes to colonic obstruction through subperitoneal fibroblast activation in colon cancer #MMPMID25613547 Yokota M ; Kojima M ; Higuchi Y ; Nishizawa Y ; Kobayashi A ; Ito M ; Saito N ; Ochiai A Cancer Sci 2015[Apr]; 106 (4 ): 466-74 PMID25613547 show ga We evaluated the influence of the cancer microenvironment formed by peritoneal invasion (CMPI) on clinical findings in colon cancer patients. In addition to the association with poor prognosis, we discovered a relationship with bowel obstruction. Detailed analysis revealed that clinical findings related to bowel obstruction occurred more frequently in patients with an elevated type tumor, which had peritoneal elastic laminal elevation to the tumor surface, compared to those with non-elevated type tumors among those with elastic laminal invasion (ELI). Lateral tumor spread and increase of tumor annularity rate in ELI-positive elevated type cases suggested the morphological progression from ELI-positive non-elevated type to elevated type. In addition, ?-smooth muscle actin expression was the highest in ELI-positive elevated type, and prominent expressions were found not only in the deep tumor area but also in the shallow tumor area. Furthermore, contraction assays revealed the robust contractile ability of subperitoneal fibroblasts stimulated by cancer cell-conditioned medium. Our findings suggest that CMPI spread into the luminal side of the colonic wall along with tumor progression, which caused bowel obstruction through the activation of subperitoneal fibroblasts. However, although the clinical outcome was not different between the two types, the clinical findings were affected by the spread of CMPI. We are the first to explore how the alteration of the tumor-promoting microenvironment, along with tumor progression, contributes to the development of clinical findings. |*Tumor Microenvironment [MESH] |Actins/biosynthesis [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Cell Line, Tumor [MESH] |Colonic Neoplasms/*pathology [MESH] |Colonic Pseudo-Obstruction/*pathology [MESH] |Culture Media, Conditioned/pharmacology [MESH] |Disease Progression [MESH] |Female [MESH] |Fibroblasts/pathology [MESH] |Humans [MESH] |Intestinal Mucosa/pathology [MESH] |Male [MESH] |Middle Aged [MESH] |Neoplasm Invasiveness [MESH] |Peritoneal Cavity/pathology [MESH] |Peritoneal Neoplasms/*pathology [MESH] |Peritoneum/pathology [MESH] |Retrospective Studies [MESH]Spread of tumor microenvironment contributes to colonic obstruction th(epmc).pdf DeepDyve Pubget Overpricing