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A new family of hybrid virophages from an animal gut metagenome #MMPMID25909276
Yutin N; Kapitonov VV; Koonin EV
Biol Direct 2015[]; 10 (ä): ä PMID25909276show ga
Search of metagenomics sequence databases for homologs of virophage capsid proteins resulted in the discovery of a new family of virophages in the sheep rumen metagenome. The genomes of the rumen virophages (RVP) encode a typical virophage major capsid protein, ATPase and protease combined with a Polinton-type, protein primed family B DNA polymerase. The RVP genomes appear to be linear molecules, with terminal inverted repeats. Thus, the RVP seem to represent virophage-Polinton hybrids that are likely capable of formation of infectious virions. Virion proteins of mimiviruses were detected in the same metagenomes as the RVP suggesting that the virophages of the new family parasitize on giant viruses that infect protist inhabitants of the rumen.This article was reviewed by Mart Krupovic and Kenneth Stedman; for complete reviews, see the Reviewers? Reports section.Electronic supplementary material: The online version of this article (doi:10.1186/s13062-015-0054-9) contains supplementary material, which is available to authorized users.