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10.1038/nature14402

http://scihub22266oqcxt.onion/10.1038/nature14402
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C4409554!4409554!25874674
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suck abstract from ncbi


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pmid25874674      Nature 2015 ; 520 (7548): 499-504
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  • Oxytocin Enables Maternal Behavior by Balancing Cortical Inhibition #MMPMID25874674
  • Marlin BJ; Mitre M; D?amour JA; Chao MV; Froemke RC
  • Nature 2015[Apr]; 520 (7548): 499-504 PMID25874674show ga
  • Oxytocin is important for social interactions and maternal behavior. However, little is known about when, where, and how oxytocin modulates neural circuits to improve social cognition. Here we show how oxytocin enables pup retrieval behavior in female mice by enhancing auditory cortical pup call responses. Retrieval behavior required left but not right auditory cortex, was accelerated by oxytocin in left auditory cortex, and oxytocin receptors were preferentially expressed in left auditory cortex. Neural responses to pup calls were lateralized, with co-tuned and temporally-precise excitatory and inhibitory responses in left cortex of maternal but not pup-naive adults. Finally, pairing calls with oxytocin enhanced responses by balancing the magnitude and timing of inhibition with excitation. Our results describe fundamental synaptic mechanisms by which oxytocin increases the salience of acoustic social stimuli. Furthermore, oxytocin-induced plasticity provides a biological basis for lateralization of auditory cortical processing.
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