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10.1074/jbc.M114.623280

http://scihub22266oqcxt.onion/10.1074/jbc.M114.623280
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suck abstract from ncbi


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pmid25752609      J+Biol+Chem 2015 ; 290 (17): 10791-803
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  • Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis* #MMPMID25752609
  • Watanabe T; Sekine S; Naguro I; Sekine Y; Ichijo H
  • J Biol Chem 2015[Apr]; 290 (17): 10791-803 PMID25752609show ga
  • Background: The molecular mechanisms of p38 MAPK-mediated necrosis currently have not been well elucidated.Results: During oxidative stress, NR4A2 is phosphorylated and translocated into the cytosol in an ASK1-p38-dependent manner, which ultimately leads to the promotion of necrosis.Conclusion: ASK1-p38 MAPK pathway-dependent phosphorylation and subsequent cytoplasmic translocation of NR4A2 promote oxidative stress-induced necrosis.Significance: We found a novel intracellular signaling pathway that regulates oxidative stress-induced and p38-mediated necrosis.
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