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10.1038/ismej.2014.214 http://scihub22266oqcxt.onion/10.1038/ismej.2014.214 C4409165!4409165 !25397946     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25397946 &cmd=llinks): Failed to open stream: HTTP request failed! 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From deep-sea volcanoes to human pathogens: a conserved quorum-sensing signal in Epsilonproteobacteria |pdf=|usr=}}{{25397946 }} gab.com Text From deep-sea volcanoes to human pathogens: a conserved quorum-sensing signal in Epsilonproteobacteria JO: ISME J http://www.kidney.de/pget.php?&tw=1&pmid=25397946 #FOAvip Chemosynthetic Epsilonproteobacteria from deep-sea hydrothermal vents colonize substrates exposed to steep thermal and redox gradients. In many bacteria, substrate attachment, biofilm formation, expression of virulence genes and host colonization are partly controlled via a cell density-dependent mechanism involving signal molecules, known as quorum sensing. Within the Epsilonproteobacteria, quorum sensing has been investigated only in human pathogens that use the luxS/autoinducer-2 (AI-2) mechanism to control the expression of some of these functions. In this study we showed that luxS is conserved in Epsilonproteobacteria and that pathogenic and mesophilic members of this class inherited this gene from a thermophilic ancestor. Furthermore, we provide evidence that the luxS gene is expressed--and a quorum-sensing signal is produced--during growth of Sulfurovum lithotrophicum and Caminibacter mediatlanticus, two Epsilonproteobacteria from deep-sea hydrothermal vents. Finally, we detected luxS transcripts in Epsilonproteobacteria-dominated biofilm communities collected from deep-sea hydrothermal vents. Taken together, our findings indicate that the epsiloproteobacterial lineage of the LuxS enzyme originated in high-temperature geothermal environments and that, in vent Epsilonproteobacteria, luxS expression is linked to the production of AI-2 signals, which are likely produced in situ at deep-sea vents. We conclude that the luxS gene is part of the ancestral epsilonproteobacterial genome and represents an evolutionary link that connects thermophiles to human pathogens. Twit Text FOAVip From deep-sea volcanoes to human pathogens: a conserved quorum-sensing signal in Epsilonproteobacteria ????ISME J http://www.kidney.de/pget.php?&tw=1&pmid=25397946 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25397946 #FOAvip English Wikipedia <ref>{{Cite pmid|25397946 }}</ref> From deep-sea volcanoes to human pathogens: a conserved quorum-sensing signal in Epsilonproteobacteria #MMPMID25397946 Pérez-Rodríguez I ; Bolognini M ; Ricci J ; Bini E ; Vetriani C ISME J 2015[May]; 9 (5 ): 1222-34 PMID25397946 show ga Chemosynthetic Epsilonproteobacteria from deep-sea hydrothermal vents colonize substrates exposed to steep thermal and redox gradients. In many bacteria, substrate attachment, biofilm formation, expression of virulence genes and host colonization are partly controlled via a cell density-dependent mechanism involving signal molecules, known as quorum sensing. Within the Epsilonproteobacteria, quorum sensing has been investigated only in human pathogens that use the luxS/autoinducer-2 (AI-2) mechanism to control the expression of some of these functions. In this study we showed that luxS is conserved in Epsilonproteobacteria and that pathogenic and mesophilic members of this class inherited this gene from a thermophilic ancestor. Furthermore, we provide evidence that the luxS gene is expressed--and a quorum-sensing signal is produced--during growth of Sulfurovum lithotrophicum and Caminibacter mediatlanticus, two Epsilonproteobacteria from deep-sea hydrothermal vents. Finally, we detected luxS transcripts in Epsilonproteobacteria-dominated biofilm communities collected from deep-sea hydrothermal vents. Taken together, our findings indicate that the epsiloproteobacterial lineage of the LuxS enzyme originated in high-temperature geothermal environments and that, in vent Epsilonproteobacteria, luxS expression is linked to the production of AI-2 signals, which are likely produced in situ at deep-sea vents. We conclude that the luxS gene is part of the ancestral epsilonproteobacterial genome and represents an evolutionary link that connects thermophiles to human pathogens. |*Oxidation-Reduction [MESH] |*Quorum Sensing [MESH] |Biofilms/growth & development [MESH] |Biological Assay [MESH] |Epsilonproteobacteria/*genetics [MESH] |Genome, Bacterial [MESH] |Homoserine/analogs & derivatives [MESH] |Humans [MESH] |Hydrothermal Vents/microbiology [MESH] |Lactones [MESH] |Likelihood Functions [MESH] |Phylogeny [MESH] |Temperature [MESH]From deep-sea volcanoes to human pathogens: a conserved quorum-sensing(epmc).pdf DeepDyve Pubget Overpricing