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10.1038/nn.3947

http://scihub22266oqcxt.onion/10.1038/nn.3947
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C4409128!4409128!25710839
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suck abstract from ncbi

pmid25710839      Nat+Neurosci 2015 ; 18 (3): 367-72
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  • Molecular mechanisms of epilepsy #MMPMID25710839
  • Staley K
  • Nat Neurosci 2015[Mar]; 18 (3): 367-72 PMID25710839show ga
  • Decades of experimental work have established an imbalance of excitation and inhibition as the leading mechanism of the transition from normal brain function to seizure. In epilepsy, these transitions are rare and abrupt. Transition processes incorporating positive feedback, such as activity-dependent disinhibition, could provide these unique timing features. A rapidly expanding array of genetic etiologies will help delineate the molecular mechanism(s). This delineation will entail quite a bit of cell biology. The genes discovered to date are currently more remarkable for their diversity than their similarities.
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