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10.1586/14787210.2014.970634

http://scihub22266oqcxt.onion/10.1586/14787210.2014.970634
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C4409121!4409121!25312349
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suck abstract from ncbi

pmid25312349      Expert+Rev+Anti+Infect+Ther 2014 ; 12 (12): 1487-99
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  • Melioidosis: Molecular Aspects of Pathogenesis #MMPMID25312349
  • Stone JK; DeShazer D; Brett PJ; Burtnick MN
  • Expert Rev Anti Infect Ther 2014[Dec]; 12 (12): 1487-99 PMID25312349show ga
  • Burkholderia pseudomallei is a Gram-negative bacterium that causes melioidosis, a multifaceted disease that is highly endemic in Southeast Asia and northern Australia. This facultative intracellular pathogen possesses a large genome that encodes a wide array of virulence factors that promote survival in vivo by manipulating host cell processes and disarming elements of the host immune system. Antigens and systems that play key roles in B. pseudomallei virulence include capsular polysaccharide, lipopolysaccharide, adhesins, specialized secretion systems, actin-based motility and various secreted factors. This review provides an overview of the current and steadily expanding knowledge regarding the molecular mechanisms used by this organism to survive within a host and their contribution to the pathogenesis of melioidosis.
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