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10.1093/toxsci/kfv038 http://scihub22266oqcxt.onion/10.1093/toxsci/kfv038 C4408963!4408963 !25666834     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25666834 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Toxicol+Sci 2015 ; 145 (1 ): 108-17 Nephropedia Template TP {{tp|p=25666834 |t=2015. Urinary ATP Synthase Subunit ? Is a Novel Biomarker of Renal Mitochondrial Dysfunction in Acute Kidney Injury |pdf=|usr=}}{{25666834 }} gab.com Text Urinary ATP Synthase Subunit Is a Novel Biomarker of Renal Mitochondrial Dysfunction in Acute Kidney Injury JO: Toxicol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25666834 #FOAvip Although the importance of mitochondrial dysfunction in acute kidney injury (AKI) has been documented, noninvasive early biomarkers of mitochondrial damage are needed. We examined urinary ATP synthase subunit ? (ATPS?) as a biomarker of renal mitochondrial dysfunction during AKI. Mice underwent sham surgery or varying degrees (5, 10, or 15?min ischemia) of ischemia/reperfusion (I/R)-induced AKI. Serum creatinine, BUN, and neutrophil gelatinase-associated lipocalin were elevated only in the 15?min I/R group at 24?h. Immunoblot analysis of urinary ATPS? revealed two bands (full length ?52?kDa and cleaved ?25?kDa), both confirmed as ATPS? by LC-MS/MS, that increased at 24?h in 10- and 15-min I/R groups. These changes were associated with mitochondrial dysfunction evidenced by reduced renal cortical expression of mitochondrial proteins, ATPS? and COX1, proximal tubular oxygen consumption, and ATP. Furthermore, in the 15-min I/R group, urinary ATPS? was elevated until 72?h before returning to baseline 144?h after reperfusion with recovery of renal function. Evaluation of urinary ATPS? in a nonalcoholic steatohepatitis model of liver injury only revealed cleaved ATPS?, suggesting specificity of full-length ATPS? for renal injury. Immunoblot analyses of patient urine samples collected 36?h after cardiac surgery revealed increased urinary ATPS? levels in patients with postcardiac surgery-induced AKI. LC-MS/MS urinalysis in human subjects with AKI confirmed increased ATPS?. These translational studies provide evidence that ATPS? may be a novel and sensitive urinary biomarker of renal mitochondrial dysfunction and could serve as valuable tool for the testing of potential therapies for AKI and chemical-induced nephrotoxicity. Twit Text FOAVip Urinary ATP Synthase Subunit Is a Novel Biomarker of Renal Mitochondrial Dysfunction in Acute Kidney Injury ????Toxicol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25666834 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25666834 #FOAvip English Wikipedia <ref>{{Cite pmid|25666834 }}</ref> Urinary ATP Synthase Subunit ? Is a Novel Biomarker of Renal Mitochondrial Dysfunction in Acute Kidney Injury #MMPMID25666834 Whitaker RM ; Korrapati MC ; Stallons LJ ; Jesinkey SR ; Arthur JM ; Beeson CC ; Zhong Z ; Schnellmann RG Toxicol Sci 2015[May]; 145 (1 ): 108-17 PMID25666834 show ga Although the importance of mitochondrial dysfunction in acute kidney injury (AKI) has been documented, noninvasive early biomarkers of mitochondrial damage are needed. We examined urinary ATP synthase subunit ? (ATPS?) as a biomarker of renal mitochondrial dysfunction during AKI. Mice underwent sham surgery or varying degrees (5, 10, or 15?min ischemia) of ischemia/reperfusion (I/R)-induced AKI. Serum creatinine, BUN, and neutrophil gelatinase-associated lipocalin were elevated only in the 15?min I/R group at 24?h. Immunoblot analysis of urinary ATPS? revealed two bands (full length ?52?kDa and cleaved ?25?kDa), both confirmed as ATPS? by LC-MS/MS, that increased at 24?h in 10- and 15-min I/R groups. These changes were associated with mitochondrial dysfunction evidenced by reduced renal cortical expression of mitochondrial proteins, ATPS? and COX1, proximal tubular oxygen consumption, and ATP. Furthermore, in the 15-min I/R group, urinary ATPS? was elevated until 72?h before returning to baseline 144?h after reperfusion with recovery of renal function. Evaluation of urinary ATPS? in a nonalcoholic steatohepatitis model of liver injury only revealed cleaved ATPS?, suggesting specificity of full-length ATPS? for renal injury. Immunoblot analyses of patient urine samples collected 36?h after cardiac surgery revealed increased urinary ATPS? levels in patients with postcardiac surgery-induced AKI. LC-MS/MS urinalysis in human subjects with AKI confirmed increased ATPS?. These translational studies provide evidence that ATPS? may be a novel and sensitive urinary biomarker of renal mitochondrial dysfunction and could serve as valuable tool for the testing of potential therapies for AKI and chemical-induced nephrotoxicity. |Acute Kidney Injury/*enzymology/physiopathology [MESH] |Aged [MESH] |Animals [MESH] |Biomarkers/*urine [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Mitochondria/*physiology [MESH]Urinary ATP Synthase Subunit ? Is a Novel Biomarker of Renal Mitochond(epmc).pdf DeepDyve Pubget Overpricing