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10.1038/nature13824 http://scihub22266oqcxt.onion/10.1038/nature13824 C4408613!4408613!25296256     free     free     free       Nature 2014 ; 514 (7522): 322-7 Nephropedia Template TP {{tp|p=25296256|t=2014. Clonal dynamics of native haematopoiesis |pdf=|usr=}}{{25296256}} gab.com Text Clonal dynamics of native haematopoiesis JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=25296256 #FOAvip It is currently thought that life-long blood cell production is driven by the action of a small number of multipotent haematopoietic stem cells. Evidence supporting this view has been largely acquired through the use of functional assays involving transplantation. However, whether these mechanisms also govern native non-transplant haematopoiesis is entirely unclear. Here we have established a novel experimental model in mice where cells can be uniquely and genetically labelled in situ to address this question. Using this approach, we have performed longitudinal analyses of clonal dynamics in adult mice that reveal unprecedented features of native haematopoiesis. In contrast to what occurs following transplantation, steady-state blood production is maintained by the successive recruitment of thousands of clones, each with a minimal contribution to mature progeny. Our results demonstrate that a large number of long-lived progenitors, rather than classically defined haematopoietic stem cells, are the main drivers of steady-state haematopoiesis during most of adulthood. Our results also have implications for understanding the cellular origin of haematopoietic disease. Twit Text FOAVip Clonal dynamics of native haematopoiesis ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=25296256 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25296256 #FOAvip English Wikipedia <ref>{{Cite pmid|25296256}}</ref> Clonal dynamics of native haematopoiesis #MMPMID25296256 Sun J; Ramos A; Chapman B; Johnnidis JB; Le L; Ho YJ; Klein A; Hofmann O; Camargo FD Nature 2014[Oct]; 514 (7522): 322-7 PMID25296256show ga It is currently thought that life-long blood cell production is driven by the action of a small number of multipotent haematopoietic stem cells. Evidence supporting this view has been largely acquired through the use of functional assays involving transplantation. However, whether these mechanisms also govern native non-transplant haematopoiesis is entirely unclear. Here we have established a novel experimental model in mice where cells can be uniquely and genetically labelled in situ to address this question. Using this approach, we have performed longitudinal analyses of clonal dynamics in adult mice that reveal unprecedented features of native haematopoiesis. In contrast to what occurs following transplantation, steady-state blood production is maintained by the successive recruitment of thousands of clones, each with a minimal contribution to mature progeny. Our results demonstrate that a large number of long-lived progenitors, rather than classically defined haematopoietic stem cells, are the main drivers of steady-state haematopoiesis during most of adulthood. Our results also have implications for understanding the cellular origin of haematopoietic disease. äClonal dynamics of native haematopoiesis (epmc).pdf DeepDyve Pubget Overpricing