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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Rev+Immunol 2011 ; 11 (10): 645-57 Nephropedia Template TP
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NK cell development, homeostasis and function: parallels with CD8+ T cells #MMPMID21869816
Sun JC; Lanier LL
Nat Rev Immunol 2011[Oct]; 11 (10): 645-57 PMID21869816show ga
Natural killer cells survey host tissues for signs of infection, transformation, or stress, and true to their name, kill target cells that have become useless or are detrimental to the host. For decades, NK cells have been classified as a component of innate immunity. However, accumulating evidence in mouse and human suggests that, like T and B cells of adaptive immunity, NK cells are educated during development, possess antigen-specific receptors, undergo clonal expansion during infection, and generate long-lived memory cells. In this review, we will highlight the many stages that an NK cell progresses through during its remarkable lifetime, discussing similarities and differences with its close relative, the cytotoxic CD8+ T cell.