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2015 ; 151
(1
): 7-17
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Quantum dots-based tissue and in vivo imaging in breast cancer researches:
current status and future perspectives
#MMPMID25833213
Wang LW
; Peng CW
; Chen C
; Li Y
Breast Cancer Res Treat
2015[May]; 151
(1
): 7-17
PMID25833213
show ga
As the most common malignant tumor for females, breast cancer (BC) is a highly
heterogeneous disease regarding biological behaviors. Precisely targeted imaging
on BC masses and biomarkers is critical to BC detection, treatment, monitoring,
and prognostic evaluation. As an important imaging technique, quantum dots
(QDs)-based imaging has emerged as a promising tool in BC researches owe to its
outstanding optical properties. However, few reviews have been specifically
devoted to discussing applications of QDs-based imaging in BC researches. This
review summarized recent promising works in QDs-based tissue and in vivo imaging
for BC studies. Physicochemical and optical properties of QDs and its potential
applications were briefly described first. Then QDs-based imaging studies in BC
were systematically reviewed, including tissue imaging for studying biomarkers
interactions, and evaluating prognostic biomarkers, in vivo imaging for mapping
axillary lymphatic system, showing BC xenograft tumor, and detecting BC
metastases. At last, the future perspectives with special emphasis on the
potential clinical applications have also been discussed. Potential applications
of QDs-based imaging on clinical BC in the future are mainly focused on tissue
study, especially in BC molecular pathology due to its optimal optical properties
and quantitative information capabilities on multiple biomarkers.