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10.1126/science.1172702 http://scihub22266oqcxt.onion/10.1126/science.1172702 C4408196!4408196!19797626     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2009 ; 326 (5955): 986-91 Nephropedia Template TP {{tp|p=19797626|t=2009. CD4+ regulatory T cells control Th17 responses in a Stat3-dependent manner |pdf=|usr=}}{{19797626}} gab.com Text CD4+ regulatory T cells control Th17 responses in a Stat3-dependent manner JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=19797626 #FOAvip Distinct classes of protective immunity are guided by activation of STAT transcription factor (TF) family members in response to environmental cues. CD4+ regulatory T cells (Tregs) suppress excessive immune responses, and their deficiency results in a lethal, multi-organ autoimmune syndrome characterized by T helper 1 (Th1) and T helper 2 (Th2) CD4+ T cell-dominated lesions. Here we show that pathogenic Th17 responses in mice are also restrained by Tregs. This suppression was lost upon Treg-specific ablation of Stat3, a TF critical for Th17 differentiation, and resulted in the development of a fatal intestinal inflammation. These findings suggest that Tregs adapt to their environment by engaging distinct effector response-specific suppression modalities upon activation of STAT proteins that direct the corresponding class of the immune response. Twit Text FOAVip CD4+ regulatory T cells control Th17 responses in a Stat3-dependent manner ????Science http://www.kidney.de/pget.php?&tw=1&pmid=19797626 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19797626 #FOAvip English Wikipedia <ref>{{Cite pmid|19797626}}</ref> CD4+ regulatory T cells control Th17 responses in a Stat3-dependent manner #MMPMID19797626 Chaudhry A; Rudra D; Treuting P; Samstein RM; Liang Y; Kas A; Rudensky AY Science 2009[Nov]; 326 (5955): 986-91 PMID19797626show ga Distinct classes of protective immunity are guided by activation of STAT transcription factor (TF) family members in response to environmental cues. CD4+ regulatory T cells (Tregs) suppress excessive immune responses, and their deficiency results in a lethal, multi-organ autoimmune syndrome characterized by T helper 1 (Th1) and T helper 2 (Th2) CD4+ T cell-dominated lesions. Here we show that pathogenic Th17 responses in mice are also restrained by Tregs. This suppression was lost upon Treg-specific ablation of Stat3, a TF critical for Th17 differentiation, and resulted in the development of a fatal intestinal inflammation. These findings suggest that Tregs adapt to their environment by engaging distinct effector response-specific suppression modalities upon activation of STAT proteins that direct the corresponding class of the immune response. äCD4+ regulatory T cells control Th17 responses in a Stat3-dependent ma(epmc).pdf DeepDyve Pubget Overpricing