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10.1111/sdi.12255

http://scihub22266oqcxt.onion/10.1111/sdi.12255
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C4407993!4407993!24962903
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suck abstract from ncbi


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pmid24962903      Semin+Dial 2015 ; 28 (2): 198-205
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  • Thrombosis in the uremic milieu- emerging role of ?thrombolome? #MMPMID24962903
  • Moshe S; Francis J; Chitalia V
  • Semin Dial 2015[Mar]; 28 (2): 198-205 PMID24962903show ga
  • Chronic kidney disease (CKD) is characterized by retention of a number of toxins, which unleash cellular damage. CKD environment with these toxins and a host of metabolic abnormalities (collectively termed as uremic milieu) is highly thrombogenic. CKD represents a strong and independent risk factor for both spontaneous venous and arterial (post-vascular injury) thrombosis. Emerging evidence points to a previously unrecognized role of some of the pro-thrombotic uremic toxins. Here we provide an overview of thrombosis in CKD and an update on indolic uremic toxins, which robustly increase tissue factor, a potent pro-coagulant, in several vascular cell-types enhancing thrombosis. This panel of uremic toxins, which we term ?thrombolome? (thrombosis and metabolome), represents a novel risk factor for thrombosis and can be further explored as biomarkers for post-vascular interventional thrombosis in patients with CKD.
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