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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Pharmacol+Exp+Ther
2015 ; 353
(2
): 235-45
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Activators of G protein signaling in the kidney
#MMPMID25628392
Park F
J Pharmacol Exp Ther
2015[May]; 353
(2
): 235-45
PMID25628392
show ga
Heterotrimeric G proteins play a crucial role in regulating signal processing to
maintain normal cellular homeostasis, and subtle perturbations in its activity
can potentially lead to the pathogenesis of renal disorders or diseases.
Cell-surface receptors and accessory proteins, which normally modify and organize
the coupling of individual G protein subunits, contribute to the regulation of
heterotrimeric G protein activity and their convergence and/or divergence of
downstream signaling initiated by effector systems. Activators of G protein
signaling (AGS) are a family of accessory proteins that intervene at multiple
distinct points during the activation-inactivation cycle of G proteins, even in
the absence of receptor stimulation. Perturbations in the expression of
individual AGS proteins have been reported to modulate signal transduction
pathways in a wide array of diseases and disorders within the brain, heart,
immune system, and more recently, the kidney. This review will provide an
overview of the expression profile, localization, and putative biologic role of
the AGS family in the context of normal and diseased states of the kidney.
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