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10.1146/annurev-immunol-032414-112123

http://scihub22266oqcxt.onion/10.1146/annurev-immunol-032414-112123
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C4407497!4407497!25706098
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suck abstract from ncbi

pmid25706098      Annu+Rev+Immunol 2015 ; 33 (ä): 747-85
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  • Interleukin-22: immunobiology and pathology #MMPMID25706098
  • Dudakov JA; Hanash AM; van den Brink MR
  • Annu Rev Immunol 2015[Mar]; 33 (ä): 747-85 PMID25706098show ga
  • Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T-helper (Th)-17 cells, ?? T cells, NKT cells and newly described innate lymphoid cells (ILCs). Knowledge of IL-22 biology has rapidly evolved since its discovery in 2000, and a role for IL-22 has been identified in numerous tissues including the intestines, lung, liver, kidney, thymus, pancreas and skin. IL-22 primarily targets non-hematopoietic epithelial and stromal cells where it can promote proliferation and play a role in tissue regeneration. In addition, IL-22 regulates host defense at barrier surfaces. However, IL-22 has also been linked to several conditions involving inflammatory tissue pathology. In this review, we will assess the current understanding of this cytokine, including its physiologic and pathologic effects on epithelial cell function.
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