Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25753410
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cell+Rep
2015 ; 10
(9
): 1443-1449
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Regulation of Autocrine Signaling in Subsets of Sympathetic Neurons Has Regional
Effects on Tissue Innervation
#MMPMID25753410
McWilliams TG
; Howard L
; Wyatt S
; Davies AM
Cell Rep
2015[Mar]; 10
(9
): 1443-1449
PMID25753410
show ga
The regulation of innervation by target-derived factors like nerve growth factor
(NGF) is the cornerstone of neurotrophic theory. Whereas autocrine signaling in
neurons affecting survival and axon growth has been described, it is difficult to
reconcile autocrine signaling with the idea that targets control their
innervation. Here, we report that an autocrine signaling loop in developing mouse
sympathetic neurons involving CD40L (TNFSF5) and CD40 (TNFRSF5) selectively
enhances NGF-promoted axon growth and branching, but not survival, via CD40L
reverse signaling. Because NGF negatively regulates CD40L and CD40 expression,
this signaling loop operates only in neurons exposed to low levels of NGF.
Consequently, the sympathetic innervation density of tissues expressing low NGF
is significantly reduced in CD40-deficient mice, whereas the innervation density
of tissues expressing high levels of NGF is unaffected. Our findings reveal how
differential regulation of autocrine signaling in neurons has region-specific
effects on axon growth and tissue innervation.