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10.1093/brain/awv039

http://scihub22266oqcxt.onion/10.1093/brain/awv039
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C4407188!4407188!25753484
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suck abstract from ncbi


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pmid25753484      Brain 2015 ; 138 (5): 1167-81
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  • Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis #MMPMID25753484
  • Liu KX; Edwards B; Lee S; Finelli MJ; Davies B; Davies KE; Oliver PL
  • Brain 2015[May]; 138 (5): 1167-81 PMID25753484show ga
  • Oxidative stress is a key factor contributing to motor neuron injury in amyotrophic lateral sclerosis (ALS). Liu et al. show that overexpression of oxidation resistance 1 (Oxr1) in neurons reduces pathology and extends lifespan in an ALS mouse model. Manipulation of OXR1 levels may have therapeutic benefit in neurodegenerative disease.
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