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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Nephrol 2015 ; 41 (2): 121-8 Nephropedia Template TP
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One-Year Mortality Rates in US Children with End-Stage Renal Disease #MMPMID25766310
Chavers BM; Molony JT; Solid CA; Rheault MN; Collins AJ
Am J Nephrol 2015[]; 41 (2): 121-8 PMID25766310show ga
Background: Few published data describe survival rates for pediatric end-stage renal disease (ESRD) patients. We aimed to describe 1-year mortality rates for US pediatric ESRD patients over a 15-year period. Summary: In this retrospective cohort study, we used the United States Renal Data System database to identify period prevalent cohorts of patients aged younger than 19 years for each year 1995?2010. Yearly cohorts averaged approximately 1200 maintenance dialysis patients (60% hemodialysis, 40% peritoneal dialysis) and 1100 transplant recipients. Patients were followed for up to 1 year and censored at change in modality, loss to follow-up, or death. We calculated unadjusted model-based mortality rates per time at risk, within each cohort year, by treatment modality (hemodialysis, peritoneal dialysis, transplant) and patient characteristics; percentage of deaths by cause; and overall adjusted odds of mortality by characteristics and modality. Approximately 50% of patients were aged 15?18 years, 55% were male, and 45% were female. The most common causes of ESRD were congenital/reflux/obstructive causes (55%) and glomerulonephritis (30%). One-year mortality rates showed evidence of a decrease for peritoneal dialysis patients (6.03 per 100 patient-years, 1995; 2.43, 2010; P = 0.0263). Mortality rates for transplant recipients (average 0.68 per 100 patient-years) were consistently lower than rates for all dialysis patients (average 4.36 per 100 patient-years). Key Message: One-year mortality rates differ by treatment modality in pediatric ESRD patients.