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10.1038/ni.3118 http://scihub22266oqcxt.onion/10.1038/ni.3118 C4406811!4406811 !25774715     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25774715 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Nat+Immunol 2015 ; 16 (5 ): 467-75 Nephropedia Template TP {{tp|p=25774715 |t=2015. The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection |pdf=|usr=}}{{25774715 }} gab.com Text The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25774715 #FOAvip Inflammasomes are critical for mounting host defense against pathogens. The molecular mechanisms that control activation of the AIM2 inflammasome in response to different cytosolic pathogens remain unclear. Here we found that the transcription factor IRF1 was required for activation of the AIM2 inflammasome during infection with the Francisella tularensis subspecies novicida (F. novicida), whereas engagement of the AIM2 inflammasome by mouse cytomegalovirus (MCMV) or transfected double-stranded DNA did not require IRF1. Infection of F. novicida detected by the DNA sensor cGAS and its adaptor STING induced type I interferon-dependent expression of IRF1, which drove the expression of guanylate-binding proteins (GBPs); this led to intracellular killing of bacteria and DNA release. Our results reveal a specific requirement for IRF1 and GBPs in the liberation of DNA for sensing by AIM2 depending on the pathogen encountered by the cell. Twit Text FOAVip The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25774715 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25774715 #FOAvip English Wikipedia <ref>{{Cite pmid|25774715 }}</ref> The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection #MMPMID25774715 Man SM ; Karki R ; Malireddi RK ; Neale G ; Vogel P ; Yamamoto M ; Lamkanfi M ; Kanneganti TD Nat Immunol 2015[May]; 16 (5 ): 467-75 PMID25774715 show ga Inflammasomes are critical for mounting host defense against pathogens. The molecular mechanisms that control activation of the AIM2 inflammasome in response to different cytosolic pathogens remain unclear. Here we found that the transcription factor IRF1 was required for activation of the AIM2 inflammasome during infection with the Francisella tularensis subspecies novicida (F. novicida), whereas engagement of the AIM2 inflammasome by mouse cytomegalovirus (MCMV) or transfected double-stranded DNA did not require IRF1. Infection of F. novicida detected by the DNA sensor cGAS and its adaptor STING induced type I interferon-dependent expression of IRF1, which drove the expression of guanylate-binding proteins (GBPs); this led to intracellular killing of bacteria and DNA release. Our results reveal a specific requirement for IRF1 and GBPs in the liberation of DNA for sensing by AIM2 depending on the pathogen encountered by the cell. |Animals [MESH] |Bacteriolysis/genetics [MESH] |Cells, Cultured [MESH] |DNA, Bacterial/genetics [MESH] |DNA-Binding Proteins/*metabolism [MESH] |DNA/immunology [MESH] |Francisella tularensis/*physiology [MESH] |GTP-Binding Proteins/*metabolism [MESH] |Gene Expression Regulation/genetics [MESH] |Inflammasomes/*metabolism [MESH] |Interferon Regulatory Factor-1/genetics/*metabolism [MESH] |Interferon Type I/metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Nucleotidyltransferases/metabolism [MESH]The transcription factor IRF1 and guanylate-binding proteins target ac(epmc).pdf DeepDyve Pubget Overpricing