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10.1007/s00467-014-3031-0 http://scihub22266oqcxt.onion/10.1007/s00467-014-3031-0 C4406792!4406792!25530085     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25530085.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Pediatr+Nephrol 2015 ; 30 (6): 983-9 Nephropedia Template TP {{tp|p=25530085|t=2015. Clinical Phenotype of APOL-1 Nephropathy in Young Relatives of Patients with End Stage Renal Disease |pdf=|usr=}}{{25530085}} gab.com Text Clinical Phenotype of APOL-1 Nephropathy in Young Relatives of Patients with End Stage Renal Disease JO: Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25530085 #FOAvip Background: Two coding variants, G1 and G2, in the apolipoprotein L-1 (APOL1) gene are associated with increased incidence of ESRD in the adult African American population. These variants associate with hypertension attributed renal disease, focal segmental glomerulosclerosis and HIV associated nephropathy. We hypothesized that as a genetic disease, APOL1 nephropathy has a pediatric phenotype. Methods: We investigated the incidence of APOL1 variants in young African Americans with hypertension or focal segmental glomerulosclerosis and a family history of end stage renal disease by conducting a case-control study of 93 pediatric and young adult African Americans with hypertension or focal segmental glomerulosclerosis to determine the association with APOL1 risk variants, G1 and G2, using custom made TaqMan based allelic discrimination assays. Results: Forty of the 61 cases (66%) with a family history of kidney disease had two APOL-1 risk variants, significantly higher than the prevalence in the case controls and the general African American population (p < 0.001). 24/29 patients with hypertension attributed kidney disease had two APOL1 risk variants while none of nine hypertensive patients without kidney disease had more than one risk allele. Conclusions: Although a small cohort, our findings strongly suggest for the first time that 2 APOL1 risk alleles in hypertensive young African Americans with a family history of ESRD are strongly associated with kidney disease. Twit Text FOAVip Clinical Phenotype of APOL-1 Nephropathy in Young Relatives of Patients with End Stage Renal Disease ????Pediatr Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25530085 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25530085 #FOAvip English Wikipedia <ref>{{Cite pmid|25530085}}</ref> Clinical Phenotype of APOL-1 Nephropathy in Young Relatives of Patients with End Stage Renal Disease #MMPMID25530085 AnyaegbuI EI; Shaw AS; Hruska KA; Jain S Pediatr Nephrol 2015[Jun]; 30 (6): 983-9 PMID25530085show ga Background: Two coding variants, G1 and G2, in the apolipoprotein L-1 (APOL1) gene are associated with increased incidence of ESRD in the adult African American population. These variants associate with hypertension attributed renal disease, focal segmental glomerulosclerosis and HIV associated nephropathy. We hypothesized that as a genetic disease, APOL1 nephropathy has a pediatric phenotype. Methods: We investigated the incidence of APOL1 variants in young African Americans with hypertension or focal segmental glomerulosclerosis and a family history of end stage renal disease by conducting a case-control study of 93 pediatric and young adult African Americans with hypertension or focal segmental glomerulosclerosis to determine the association with APOL1 risk variants, G1 and G2, using custom made TaqMan based allelic discrimination assays. Results: Forty of the 61 cases (66%) with a family history of kidney disease had two APOL-1 risk variants, significantly higher than the prevalence in the case controls and the general African American population (p < 0.001). 24/29 patients with hypertension attributed kidney disease had two APOL1 risk variants while none of nine hypertensive patients without kidney disease had more than one risk allele. Conclusions: Although a small cohort, our findings strongly suggest for the first time that 2 APOL1 risk alleles in hypertensive young African Americans with a family history of ESRD are strongly associated with kidney disease. äClinical Phenotype of APOL-1 Nephropathy in Young Relatives of Patient(epmc).pdf DeepDyve Pubget Overpricing